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首页  >  重组蛋白  >  Human ABCG2 Recombinant Protein
ABCG2 (基因名), ATP-binding cassette sub-family G member 2 (蛋白名), ABCG2_HUMAN.
产品名称:

Human ABCG2/ ATP-binding cassette sub-family G member 2 Recombinant Protein
腺苷三磷酸结合盒转运蛋白G2

货号:

R0960h

商标:
EIAab®
监管等级:
别名:

Breast cancer resistance protein, CDw338, Mitoxantrone resistance-associated protein, Placenta-specific ATP-binding cassette transporter, Urate exporter, CD338, ABCP, BCRP, BCRP1, MXR

序列号:
Q9UNQ0
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human ABCG2 Protein
规格 & 价格: cart
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Human ABCG2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 4q22.1 by HGNC 4q22.1 by Entrez Gene 4q22.1 by Ensembl
ABCG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Monomer under reducing conditions, the minimal functional units is a homodimer; disulfide-linked, but the major oligomeric form in plasma membranes is a homotetramer with possibility of higher order oligomerization up to homododecamers.


功能:
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.


亚细胞位置:
Cell membrane Multi-pass membrane protein Mitochondrion membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation."

[2].
"ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin."

[3].
"Identification and functional characterization of breast cancer resistance protein in human bronchial epithelial cells (Calu-3)."

[4].
"Telmisartan pharmacokinetics in Japanese renal transplant recipients."

[5].
"Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2."
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