首页 > 重组蛋白 > Human ABCA4 Recombinant Protein

ABCA4 (基因名), Retinal-specific phospholipid-transporting ATPase ABCA4 (蛋白名), ABCA4_HUMAN.

产品名称:

Human ABCA4/ Retinal-specific phospholipid-transporting ATPase ABCA4 Recombinant Protein
视网膜特异性磷脂转运atp酶ABCA4

货号:

R10399h

商标:

EIAab^®

监管等级:

RUO

别名:

ATP-binding cassette sub-family A member 4, RIM ABC transporter, Retinal-specific ATP-binding cassette transporter, Stargardt disease protein, RIM protein, ABCR

序列号:

P78363

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human ABCA4 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 1p22.1 by HGNC 1p22.1 by Entrez Gene 1p22.1 by Ensembl

ABCA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

N/A

功能:

Catalyzes the translocation of specific phospholipids from the extracellular/lumenal to the cytoplasmic leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylethanolamine (PubMed:24097981). In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.

亚细胞位置:

Membrane Multi-pass membrane protein Endoplasmic reticulum Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor.

数据库链接

UniGene:

Hs.416707

SMR:

P78363

STRING:

9606.ENSP00000359245

KEGG:

hsa:24

MIM:

153800

Pfam:

PF00005

Uniprot:

P78363

相关产品

Mouse Abca4 ELISA Kit

Mouse Abca4 CLIA Kit

Mouse Abca4 Protein

Mouse Abca4 Polyclonal Antibody

Mouse Abca4 Monoclonal Antibody

序列长度:

2273

序列:

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AAGASRQAQD |

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Molecular analysis of the ABCA4 gene for reliable detection of allelic variations in Spanish patients: identification of 21 novel variants."

(PMID: 19028736)

[2].

"Late-onset Stargardt disease is associated with missense mutations that map outside known functional regions of ABCR (ABCA4)."

(PMID: 11379881)

[3].

"Variation of codons 1961 and 2177 of the Stargardt disease gene is not associated with age-related macular degeneration."

(PMID: 11346402)

[4].

"An analysis of allelic variation in the ABCA4 gene."

(PMID: 11328725)

[5].

"Frequency of ABCA4 mutations in 278 Spanish controls: an insight into the prevalence of autosomal recessive Stargardt disease."

(PMID: 18977788)

[6].

"Genetic and epigenetic factors at COL2A1 and ABCA4 influence clinical outcome in congenital toxoplasmosis."

(PMID: 18523590)

[7].

"ABCA4 gene analysis in patients with autosomal recessive cone and cone rod dystrophies."

(PMID: 18285826)

[8].

"N965S is a common ABCA4 variant in Stargardt-related retinopathies in the Danish population."

(PMID: 17982420)

[9].

"Spectrum of the ABCA4 gene mutations implicated in severe retinopathies in Spanish patients."

(PMID: 17325136)

[10].

"Microarray-based mutation analysis of the ABCA4 (ABCR) gene in autosomal recessive cone-rod dystrophy and retinitis pigmentosa."

(PMID: 15494742)

[1].

人视网膜特异性磷脂转运atp酶ABCA4(ABCA4)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人视网膜特异性磷脂转运atp酶ABCA4(ABCA4)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人视网膜特异性磷脂转运atp酶ABCA4(ABCA4)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人视网膜特异性磷脂转运atp酶ABCA4(ABCA4)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人视网膜特异性磷脂转运atp酶ABCA4(ABCA4)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人视网膜特异性磷脂转运atp酶ABCA4(ABCA4)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人视网膜特异性磷脂转运atp酶ABCA4(ABCA4)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人视网膜特异性磷脂转运atp酶ABCA4(ABCA4)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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