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ABCA1 (基因名), Phospholipid-transporting ATPase ABCA1 (蛋白名), ABCA1_HUMAN.
产品名称:

Human ABCA1/ Phospholipid-transporting ATPase ABCA1 Recombinant Protein
腺苷三磷酸结合盒转运蛋白A1

货号:

R1242h

商标:
EIAab®
监管等级:
别名:

ATP-binding cassette sub-family A member 1, ATP-binding cassette transporter 1, Cholesterol efflux regulatory protein, ABC-1, ABC1, CERP

序列号:
O95477
来源:
E.coli
种属:
Human
标签:
His
序列:
Recombinant Protein
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cardiovascular
Human ABCA1 Protein
规格 & 价格: cart
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Human ABCA1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 9q31.1 by HGNC 9q31.1 by Entrez Gene 9q31.1 by Ensembl
ABCA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with MEGF10 (PubMed:17205124). May interact with APOE1; functionally associated with APOE1 in the biogenesis of HDLs (PubMed:14754908).


功能:
Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Thereby, participates to phospholipids transfer to apoliproteins to form nascent high density lipoproteins/HDLs (PubMed:14754908). Transports preferentially phosphatidylcholine over phosphatidylserine (PubMed:24097981). May involved indirectly in the efflux of intracellular cholesterol and its transfer to apoliproteins to form nascent high density lipoproteins/HDLs (PubMed:10533863, PubMed:14754908, PubMed:24097981).


亚细胞位置:
Membrane Multi-pass membrane protein Cell membrane Endosome



[1].
"Screening for functional sequence variations and mutations in ABCA1."

[2].
"ABCA1 gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore."

[3].
"A common variant in the ABCA1 gene is associated with a lower risk for premature coronary heart disease in familial hypercholesterolaemia."

[4].
"Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1."

[5].
"Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal women."
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