APOBEC3H (基因名), DNA dC->dU-editing enzyme APOBEC-3H (蛋白名), ABC3H_HUMAN.
Human APOBEC3H/ DNA dC->dU-editing enzyme APOBEC-3H Recombinant Protein
APOBEC-related protein 10, Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H, ARP-10, A3H
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Interacts with AGO1, AGO2 and AGO3.
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
Nucleus Cytoplasm Cytoplasm P-body Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.
MALLTAETFR | LQFNNKRRLR | RPYYPRKALL | CYQLTPQNGS | TPTRGYFENK |
KKCHAEICFI | NEIKSMGLDE | TQCYQVTCYL | TWSPCSSCAW | ELVDFIKAHD |
HLNLGIFASR | LYYHWCKPQQ | KGLRLLCGSQ | VPVEVMGFPK | FADCWENFVD |
HEKPLSFNPY | KMLEELDKNS | RAIKRRLERI | KIPGVRAQGR | YMDILCDAEV |
"Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H."
"APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophages."
"HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."
"APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1."
"Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."
"Polymorphism in human APOBEC3H affects a phenotype dominant for subcellular localization and antiviral activity."
"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."
"APOBEC3 proteins mediate the clearance of foreign DNA from human cells."
"Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction."
"Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1."
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