APOBEC3C (基因名), DNA dC->dU-editing enzyme APOBEC-3C (蛋白名), ABC3C_HUMAN.
Human APOBEC3C/ DNA dC->dU-editing enzyme APOBEC-3C Recombinant Protein
APOBEC1-like, Phorbolin I, A3C, APOBEC1L, PBI
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Homodimer. Interacts with human foamy virus protein Bet; this interaction does not induce APOBEC3C degradation, but prevents dimerization and incorporation into virion of the latter. Interacts with TRIB3 and AGO2.
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
MNPQIRNPMK | AMYPGTFYFQ | FKNLWEANDR | NETWLCFTVE | GIKRRSVVSW |
KTGVFRNQVD | SETHCHAERC | FLSWFCDDIL | SPNTKYQVTW | YTSWSPCPDC |
AGEVAEFLAR | HSNVNLTIFT | ARLYYFQYPC | YQEGLRSLSQ | EGVAVEIMDY |
EDFKYCWENF | VYNDNEPFKP | WKGLKTNFRL | LKRRLRESLQ |
"An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22."
"Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."
"HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."
"Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain."
"Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo."
"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."
"APOBEC3 proteins mediate the clearance of foreign DNA from human cells."
"Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet."
"The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements."
"Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H."
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