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首页  >  重组蛋白  >  Human APOBEC3B Recombinant Protein
APOBEC3B (基因名), DNA dC->dU-editing enzyme APOBEC-3B (蛋白名), ABC3B_HUMAN.
产品名称:

Human APOBEC3B/ DNA dC->dU-editing enzyme APOBEC-3B Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Phorbolin-1-related protein, Phorbolin-2/3, A3B

序列号:
Q9UH17
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human APOBEC3B Protein
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Human APOBEC3B Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 22q13.1 by HGNC 22q13.1 by Entrez Gene 22q13.1 by Ensembl
APOBEC3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer. Interacts with APOBEC3G. Does not interact with APOBEC1.


功能:
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1."

[2].
"APOBEC3B deletion and risk of HIV-1 acquisition."

[3].
"Population stratification of a common APOBEC gene deletion polymorphism."

[4].
"An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22."

[5].
"APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1."

[6].
"Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."

[7].
"HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."

[8].
"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."

[9].
"APOBEC3 proteins mediate the clearance of foreign DNA from human cells."

[10].
"No evidence of an association between the APOBEC3B deletion polymorphism and susceptibility to HIV infection and AIDS in Japanese and Indian populations."
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