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首页  >  重组蛋白  >  Human APOBEC3A Recombinant Protein
APOBEC3A (基因名), DNA dC->dU-editing enzyme APOBEC-3A (蛋白名), ABC3A_HUMAN.
产品名称:

Human APOBEC3A/ DNA dC->dU-editing enzyme APOBEC-3A Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Phorbolin-1, A3A

序列号:
P31941
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human APOBEC3A Protein
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Human APOBEC3A Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 22q13.1 by HGNC 22q13.1 by Entrez Gene 22q13.1 by Ensembl
APOBEC3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with AGO2. Interacts with TRIB3 (via N-terminus).


功能:
DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.


亚细胞位置:
Nucleus Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1."

[2].
"APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons."

[3].
"An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22."

[4].
"APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1."

[5].
"HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."

[6].
"Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A."

[7].
"APOBEC3A can activate the DNA damage response and cause cell-cycle arrest."

[8].
"Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain."

[9].
"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."

[10].
"Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities."
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