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HTR4 (基因名), 5-hydroxytryptamine receptor 4 (蛋白名), 5HT4R_HUMAN.
产品名称:

Human HTR4/ 5-hydroxytryptamine receptor 4 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Serotonin receptor 4, 5-HT-4

序列号:
Q13639
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human HTR4 Protein
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Human HTR4 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 5q32 by HGNC 5q32 by Entrez Gene 5q32 by Ensembl
HTR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with PATJ, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR (By similarity). Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin).


功能:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.


亚细胞位置:
Cell membrane Multi-pass membrane protein Endosome Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.


该产品尚未在任何出版物中被引用。

[1].
"Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia."

[2].
"Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus."

[3].
"Expression of serotonin receptor mRNAs in blood vessels."

[4].
"Association study of the serotoninergic system in migraine in the Spanish population."

[5].
"Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples."
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