EIF4EBP3 (基因名), Eukaryotic translation initiation factor 4E-binding protein 3 (蛋白名), 4EBP3_HUMAN.
Human EIF4EBP3/ Eukaryotic translation initiation factor 4E-binding protein 3 Recombinant Protein
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
EIF4EBP3 interacts with EIF4E.
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.
"4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family."
"Binding preference of eIF4E for 4E-binding protein isoform and function of eIF4E N-terminal flexible region for interaction, studied by SPR analysis."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK."
"Localisation and regulation of the eIF4E-binding protein 4E-BP3."
"MiR-22-3p Regulates Cell Proliferation and Inhibits Cell Apoptosis through Targeting the eIF4EBP3 Gene in Human Cervical Squamous Carcinoma Cells."
"Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3."
"Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism."
"A proteome-scale map of the human interactome network."
"LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells."
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