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EIF4EBP3 (GeneName), Eukaryotic translation initiation factor 4E-binding protein 3 (ProteinName), 4EBP3_HUMAN.
Product Name:

Human EIF4EBP3/ Eukaryotic translation initiation factor 4E-binding protein 3 Recombinant Protein

 
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

4E-BP3

Source:
E.coli
Species:
Human
Tags:
His
Purity:
>90% by SDS-PAGE
Concentration:
Reconstitution Dependent
Form:
Liquid
Storage Buffer:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Storage:
Store at -20°C. (Avoid repeated freezing and thawing.)
Research Area:
-
Human EIF4EBP3 Protein
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Product Datasheets
Instruction:
MSDS:


Genomic View
Cytogenetic band: 5q31.3 by HGNC 5q31.3 by Entrez Gene 5q31.3 by Ensembl
EIF4EBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
General Annotation


Sub Unit:
EIF4EBP3 interacts with EIF4E.


Function:
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation.


Subcellular Location:
N/A


This product has not yet been referenced specifically in any publications.
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[1].
"4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family."

[2].
"Binding preference of eIF4E for 4E-binding protein isoform and function of eIF4E N-terminal flexible region for interaction, studied by SPR analysis."

[3].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[4].
"Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK."

[5].
"Localisation and regulation of the eIF4E-binding protein 4E-BP3."

[6].
"MiR-22-3p Regulates Cell Proliferation and Inhibits Cell Apoptosis through Targeting the eIF4EBP3 Gene in Human Cervical Squamous Carcinoma Cells."

[7].
"Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3."

[8].
"Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism."

[9].
"A proteome-scale map of the human interactome network."

[10].
"LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells."
Sample Data
Sample Data
Sample Data
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