EIF4EBP1 (基因名), Eukaryotic translation initiation factor 4E-binding protein 1 (蛋白名), 4EBP1_HUMAN.
Human EIF4EBP1/ Eukaryotic translation initiation factor 4E-binding protein 1 Recombinant Protein
Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I, 4E-BP1
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Hypophosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Interacts (via TOS motif) with RPTOR; promoting phosphorylation by mTORC1 (PubMed:12747827).
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
"Associations between multiple system atrophy and polymorphisms of SLC1A4, SQSTM1, and EIF4EBP1 genes."
"Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods."
"The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation."
"Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action."
"RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1."
"Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E."
"Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function."
"Translational homeostasis via the mRNA cap-binding protein, eIF4E."
"Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes."
"4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation."
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