Mpg (GeneName), DNA-3-methyladenine glycosylase (ProteinName), 3MG_RAT.
Rat Mpg/ DNA-3-methyladenine glycosylase Recombinant Protein
3-alkyladenine DNA glycosylase,3-methyladenine DNA glycosidase,ADPG,N-methylpurine-DNA glycosylase
>90% by SDS-PAGE
Please contact the technician for more information.
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Binds MBD1. Binds SSBP1.
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Cytoplasm Mitochondrion matrix Mitochondrion nucleoid Nucleus
SKEPVSVVLP | DAEHPAFPGR | TRRPGNARAG | SQVTGSREVG | QMPAPLSRKI |
GQKKQQLAQS | EQQQTPKEKL | SSTPGLLRSI | YFSSPEDRPA | RLGPEYFDQP |
AVTLARAFLG | QVLVRRLADG | TELRGRIVET | EAYLGPEDEA | AHSRGGRQTP |
RNRGMFMKPG | TLYVYLIYGM | YFCLNVSSQG | AGACVLLRAL | EPLEGLETMR |
QLRNSLRKST | VGRSLKDREL | CNGPSKLCQA | LARSKSFDQR | DLAQDEAVWL |
EHGPLESSSP | AVVAAAAGIG | HAGEWTQKPL | RFYVQGSPWV | SVVDRVAEQM |
YQPQQTACSD | XALIVQK
This product has not yet been referenced specifically in any publications.
"Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase."
"Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin."
"Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision."
"Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse."
"Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere."
"Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16."
"Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB)."
"Hopping enables a DNA repair glycosylase to search both strands and bypass a bound protein."
"Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations."
"Variation within DNA repair pathway genes and risk of multiple sclerosis."
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