Sh3bp5 (GeneName), SH3 domain-binding protein 5 (ProteinName), 3BP5_MOUSE.
Mouse Sh3bp5/ SH3 domain-binding protein 5 Recombinant Protein
SH3BP-5,SH3 domain-binding protein that preferentially associates with BTK,Sab
>90% by SDS-PAGE
Please contact the technician for more information.
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Interacts with BTK (By similarity). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (By similarity). Interacts with GDP-bound and nucleotide-free forms of RAB11A (PubMed:26506309).
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
MDTALKRSRS | DEPAELPPPA | REVEEKEEEE | ERMEQGLEEE | EEEVDPRIQG |
ELEKLNQSTD | DINRRETELE | DARQKFRSVL | VEATVKLDEL | AKKIGKAVED |
SKPYWEARRV | ARQAQLEAQK | ATQDFQRATE | VLRAAKETIS | LAEQRLLEDD |
KRQFDSAWQE | MLNHATQRVM | EAEQTKTRSE | LVHKETAARY | NAAMGRMRQL |
EKKLKRAINK | SKPYFELKAK | YYVQLEQLKK | TVDDLQAKLA | LAKGEYKAAL |
KSLERISDEI | HERRRSNAMG | PRGCGVGAEG | SIASVENLPV | SKPEPDAISV |
ASEAFEDDNC | SNLVSEDDSE | TQSVSSFSSG | PTSPSEMPDQ | FPAVARPGSL |
DLPSPVSLSE | FGMMFPILGP | RSECSGASSP | ECEVERGDRA | EGAENKMSDK |
ANNNRVLGST | NGGSGRSRSQ | SSTSLESQAL | ETRMKQLSLQ | CSKGRDGIIA |
DIKMIFIFYT | FLQ
This product has not yet been referenced specifically in any publications.
"Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein."
"Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK)."
"Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5."
"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein."
"A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria."
"Architecture of the human interactome defines protein communities and disease networks."
"REI/SH3BP5 protein family: New GEFs for Rab11."
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