HSD3B2 (GeneName), 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (ProteinName), 3BHS2_HUMAN.
Human HSD3B2/ 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 Recombinant Protein
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II,3-beta-HSD II,3-beta-HSD adrenal and gonadal type,HSDB3B
>90% by SDS-PAGE
Please contact the technician for more information.
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
Endoplasmic reticulum membrane Single-pass membrane protein Mitochondrion membrane Single-pass membrane protein
MGWSCLVTGA | GGLLGQRIVR | LLVEEKELKE | IRALDKAFRP | ELREEFSKLQ |
NRTKLTVLEG | DILDEPFLKR | ACQDVSVVIH | TACIIDVFGV | THRESIMNVN |
VKGTQLLLEA | CVQASVPVFI | YTSSIEVAGP | NSYKEIIQNG | HEEEPLENTW |
PTPYPYSKKL | AEKAVLAANG | WNLKNGDTLY | TCALRPTYIY | GEGGPFLSAS |
INEALNNNGI | LSSVGKFSTV | NPVYVGNVAW | AHILALRALR | DPKKAPSVRG |
QFYYISDDTP | HQSYDNLNYI | LSKEFGLRLD | SRWSLPLTLM | YWIGFLLEVV |
SFLLSPIYSY | QPPFNRHTVT | LSNSVFTFSY | KKAQRDLAYK | PLYSWEEAKQ |
KTVEWVGSLV | DRHKETLKSK | TQ
This product has not yet been referenced specifically in any publications.
"Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer."
"Carboxyl-terminal mutations in 3beta-hydroxysteroid dehydrogenase type II cause severe salt-wasting congenital adrenal hyperplasia."
"Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer."
"Variant in sex hormone-binding globulin gene and the risk of prostate cancer."
"SRD5A2 and HSD3B2 polymorphisms are associated with prostate cancer risk and aggressiveness."
"Refining hormonal diagnosis of type II 3beta-hydroxysteroid dehydrogenase deficiency in patients with premature pubarche and hirsutism based on HSD3B2 genotyping."
"The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency."
"Molecular study of the 3 beta-hydroxysteroid dehydrogenase gene type II in patients with hypospadias."
"Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility."
"Mutations in the type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) gene can cause premature pubarche in girls."
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