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HSD3B2 (GeneName), 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (ProteinName), 3BHS2_HUMAN.
Product Name:

Human HSD3B2/ 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 Recombinant Protein

 
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II,3-beta-HSD II,3-beta-HSD adrenal and gonadal type,HSDB3B

Source:
E.coli
Species:
Human
Tags:
His
Purity:
>90% by SDS-PAGE
Concentration:
Reconstitution Dependent
Form:
Liquid
Endotoxin Level:
Please contact the technician for more information.
Storage Buffer:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Storage:
Store at -20°C. (Avoid repeated freezing and thawing.)
Research Area:
-
Human HSD3B2 Protein
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Product Datasheets
Instruction:
MSDS:


Genomic View
Cytogenetic band: 1p12 by HGNC 1p12 by Entrez Gene 1p12 by Ensembl
HSD3B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
General Annotation


Sub Unit:
N/A


Function:
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.


Subcellular Location:
Endoplasmic reticulum membrane Single-pass membrane protein Mitochondrion membrane Single-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer."

[2].
"Carboxyl-terminal mutations in 3beta-hydroxysteroid dehydrogenase type II cause severe salt-wasting congenital adrenal hyperplasia."

[3].
"Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer."

[4].
"Variant in sex hormone-binding globulin gene and the risk of prostate cancer."

[5].
"SRD5A2 and HSD3B2 polymorphisms are associated with prostate cancer risk and aggressiveness."

[6].
"Refining hormonal diagnosis of type II 3beta-hydroxysteroid dehydrogenase deficiency in patients with premature pubarche and hirsutism based on HSD3B2 genotyping."

[7].
"The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency."

[8].
"Molecular study of the 3 beta-hydroxysteroid dehydrogenase gene type II in patients with hypospadias."

[9].
"Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility."

[10].
"Mutations in the type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) gene can cause premature pubarche in girls."
Sample Data
Sample Data
Sample Data
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