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HSD3B1 (GeneName), 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (ProteinName), 3BHS1_HUMAN.
Product Name:

Human HSD3B1/ 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 Recombinant Protein

 
Cat.#:

R2793h

Brand:
EIAab®
Regulatory Status:
Alternative:

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I,3-beta-HSD I,3BH,HSDB3A,3-beta-hydroxy-5-ene steroid dehydrogenase,3-beta-hydroxy-Delta(5)-steroid dehydrogenase,3-beta-hydroxysteroid 3-dehydrogenase,Delta-5-3-ketosteroid isomerase,Dihydrotestosterone oxidoreductase,Steroid Delta-isomerase,Trophoblast antigen FDO161G

Source:
E.coli
Species:
Human
Tags:
His
Purity:
>90% by SDS-PAGE
Concentration:
Reconstitution Dependent
Form:
Liquid
Storage Buffer:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Storage:
Store at -20°C. (Avoid repeated freezing and thawing.)
Research Area:
Metabolism
Human HSD3B1 Protein
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Human HSD3B1 Protein
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Product Datasheets
Instruction:
MSDS:


R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Genomic View
Cytogenetic band: 1p12 by HGNC 1p12 by Entrez Gene 1p12 by Ensembl
HSD3B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
General Annotation


Sub Unit:
N/A


Function:
A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone (PubMed:1401999, PubMed:2139411). Expected to use NAD(+) as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable).


Subcellular Location:
Endoplasmic reticulum membrane Single-pass membrane protein Mitochondrion membrane Single-pass membrane protein


This product has not yet been referenced specifically in any publications.
Publishing research using this product ?
Please let us know and we will provide a credit for your next order.

[1].
"Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer."

[2].
"Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain."

[3].
"Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer."

[4].
"The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency."

[5].
"Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility."

[6].
"Molecular cloning and expression of human trophoblast antigen FDO161G and its identification as 3 beta-hydroxy-5-ene steroid dehydrogenase."

[7].
"Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenase."

[8].
"Genetic susceptibility to distinct bladder cancer subphenotypes."

[9].
"Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer."

[10].
"A Large-scale genetic association study of esophageal adenocarcinoma risk."
Sample Data
Sample Data
Sample Data
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