Ppp2r5c (GeneName), Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (ProteinName), 2A5G_MOUSE.
Mouse Ppp2r5c/ Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform Recombinant Protein
PP2A B subunit isoform B'-alpha-3,PP2A B subunit isoform B'-gamma,PP2A B subunit isoform B56-gamma,PP2A B subunit isoform PR61-gamma,PP2A B subunit isoform R5-gamma
>90% by SDS-PAGE
Please contact the technician for more information.
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1 (By similarity). Interacts with SGO1; the interaction is direct. May interact with TP53 (By similarity). Interacts with IER3 and/or ERK kinases; regulates ERK dephosphorylation.
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
Nucleus Chromosome Centromere
MLTCNKAGSG | MVVDAASSNG | PFQPVALLHI | RDVPPADQEK | LFIQKLRQCC |
VLFDFVSDPL | SDLKWKEVKR | AALSEMVEYI | THNRNVITEP | IYPEAVHMFA |
VNMFRTLPPS | SNPTGAEFDP | EEDEPTLEAA | WPHLQLVYEF | FLRFLESPDF |
QPNIAKKYID | QKFVLQLLEL | FDSEDPRERD | FLKTTLHRIY | GKFLGLRAYI |
RKQINNIFYR | FIYETEHHNG | IAELLEILGS | IINGFALPLK | EEHKIFLLKV |
LLPLHKVKSL | SVYHPQLAYC | VVQFLEKDST | LTEPVVMALL | KYWPKTHSPK |
EVMFLNELEE | ILDVIEPSEF | VKIMEPLFRQ | LAKCVSSPHF | QVAERALYYW |
NNEYIMSLIS | DNAAKILPIM | FPSLYRNSKT | HWNKTIHGLI | YNALKLFMEM |
NQKLFDDCTQ | QFKAEKLKEK | LKMKEREEAW | VKIENLAKAN | PQYAVYSQAS |
AVSIPVAMET | DGPQFEDVQM | LKKTVSDEAR | QAQKELKKDR | PLVRRKSELP |
QDPHTEKALE | AHCRASELLS | QDGR
This product has not yet been referenced specifically in any publications.
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