首页 > 重组蛋白 > Human YWHAZ Recombinant Protein

YWHAZ (基因名), 14-3-3 protein zeta/delta (蛋白名), 1433z_human.

产品名称:

Human YWHAZ/ 14-3-3 protein zeta/delta Recombinant Protein
14-3-3蛋白ζ/δ

货号:

R14294h

商标:

EIAab^®

监管等级:

RUO

别名:

Protein kinase C inhibitor protein 1, KCIP-1

序列号:

P63104

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Neurosciences

规格 & 价格:

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Human YWHAZ Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 8q22.3 by HGNC 8q22.3 by Entrez Gene 8q22.3 by Ensembl

YWHAZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with CDK16 and BSPRY (By similarity). Interacts with WEE1 (C-terminal). Interacts with SAMSN1 (By similarity). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm (By similarity). Interacts with Thr-phosphorylated ITGB2 (By similarity). Interacts with BCL2L11 (By similarity). Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58. Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization. Interacts with GAB2 and TLK2. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with ZFP36L1 (via phosphorylated form); this interaction occurs in a p38 MAPK- and AKT-signaling pathways (By similarity). Interacts with SLITRK1 (PubMed:19640509).

功能:

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

亚细胞位置:

Cytoplasm Melanosome Located to stage I to stage IV melanosomes.

数据库链接

UniGene:

Hs.492407

SMR:

P63104

STRING:

9606.ENSP00000309503

KEGG:

hsa:7534

MIM:

601288

Pfam:

PF00244

Uniprot:

P63104

相关产品

Mouse Ywhaz ELISA Kit

Rat Ywhaz ELISA Kit

Bovine YWHAZ ELISA Kit

Chicken YWHAZ ELISA Kit

Mouse Ywhaz CLIA Kit

序列长度:

245

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

200:

245:

AELDTLSEES | YKDSTLIMQL | LRDNLTLWTS | DTQGDEAEAG | EGGEN

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."

(PMID: 23572552)

[2].

"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

(PMID: 20379614)

[3].

"Examination of association of genes in the serotonin system to autism."

(PMID: 19184136)

[4].

"Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study."

(PMID: 18951430)

[5].

"Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."

(PMID: 19172738)

[6].

"14-3-3 zeta and tau genes interactively decrease Alzheimer's disease risk."

(PMID: 18319590)

[7].

"Gene-gene interaction between 14-3-3 zeta and butyrylcholinesterase modulates Alzheimer's disease risk."

(PMID: 18290843)

[8].

"Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon."

(PMID: 16376338)

[9].

"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."

(PMID: 17081065)

[10].

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."

(PMID: 17081983)

[1].

人14-3-3蛋白ζ/δ(YWHAZ)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人14-3-3蛋白ζ/δ(YWHAZ)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人14-3-3蛋白ζ/δ(YWHAZ)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人14-3-3蛋白ζ/δ(YWHAZ)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人14-3-3蛋白ζ/δ(YWHAZ)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人14-3-3蛋白ζ/δ(YWHAZ)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人14-3-3蛋白ζ/δ(YWHAZ)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人14-3-3蛋白ζ/δ(YWHAZ)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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