Ywhaz (基因名), 14-3-3 protein zeta/delta (蛋白名), 1433Z_RAT.
Rat Ywhaz/ 14-3-3 protein zeta/delta Recombinant Protein
Mitochondrial import stimulation factor S1 subunit, Protein kinase C inhibitor protein 1, KCIP-1, Msfs1
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Homodimer. Heterodimerizes with YWHAE (By similarity). Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58 (By similarity). Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with CDK16 and with WEE1 (C-terminal). Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with Thr-phosphorylated ITGB2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization (By similarity). Interacts with GAB2 and SAMSN1. Binds to TLK2 (By similarity). Interacts with BSPRY. Interacts with BCL2L11. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with ZFP36L1 (via phosphorylated form); this interaction occurs in a p38 MAPK- and AKT-signaling pathways (By similarity). Interacts with SLITRK1.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Cytoplasm Melanosome Located to stage I to stage IV melanosomes.
MDKNELVQKA | KLAEQAERYD | DMAACMKSVT | EQGAELSNEE | RNLLSVAYKN |
VVGARRSSWR | VVSSIEQKTE | GAEKKQQMAR | EYREKIETEL | RDICNDVLSL |
LEKFLIPNAS | QPESKVFYLK | MKGDYYRYLA | EVAAGDDKKG | IVDQSQQAYQ |
EAFEISKKEM | QPTHPIRLGL | ALNFSVFYYE | ILNSPEKACS | LAKTAFDEAI |
AELDTLSEES | YKDSTLIMQL | LRDNLTLWTS | DTQGDEAEAG | EGGEN
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