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Home  >  Protein  >  Human YWHAQ Recombinant Protein
YWHAQ (GeneName), 14-3-3 protein theta (ProteinName), 1433T_HUMAN.
Product Name:

Human YWHAQ/ 14-3-3 protein theta Recombinant Protein

 
Cat.#:

R14293h

Brand:
EIAab®
Regulatory Status:
Alternative:

14-3-3 protein T-cell,14-3-3 protein tau,Protein HS1

Source:
E.coli
Species:
Human
Tags:
His
Sequence:
Recombinant protein
Purity:
>90% by SDS-PAGE
Concentration:
Reconstitution Dependent
Form:
Liquid
Endotoxin Level:
Please contact the technician for more information.
Storage Buffer:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Storage:
Store at -20°C. (Avoid repeated freezing and thawing.)
Research Area:
Cancer
Human YWHAQ Protein
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Product Datasheets
Instruction:
MSDS:


R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Genomic View
Cytogenetic band: 2p25.1 by HGNC 2p25.1 by Entrez Gene 2p25.1 by Ensembl
YWHAQ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
General Annotation


Sub Unit:
Homodimer. Interacts with CDK16 (By similarity). Interacts with RGS7 (phosphorylated form) (PubMed:10862767). Interacts with SSH1. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with the 'Ser-241' phosphorylated form of PDPK1. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509).


Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.


Subcellular Location:
Cytoplasm In neurons, axonally transported to the nerve terminals.


This product has not yet been referenced specifically in any publications.

[1].
"A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord."

[2].
"An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes."

[3].
"Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils."

[4].
"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."

[5].
"Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study."

[6].
"SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner."

[7].
"Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."

[8].
"Structural basis for protein-protein interactions in the 14-3-3 protein family."

[9].
"A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia."

[10].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Sample Data
Sample Data
Sample Data
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