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YWHAG (GeneName), 14-3-3 protein gamma (ProteinName), 1433G_HUMAN.
Product Name:

Human YWHAG/ 14-3-3 protein gamma Recombinant Protein

 
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Protein kinase C inhibitor protein 1,KCIP-1

Source:
E.coli
Species:
Human
Tags:
His
Purity:
>90% by SDS-PAGE
Concentration:
Reconstitution Dependent
Form:
Liquid
Storage Buffer:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Storage:
Store at -20°C. (Avoid repeated freezing and thawing.)
Research Area:
Cancer
Human YWHAG Protein
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Human YWHAG Protein
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Product Datasheets
Instruction:
MSDS:


Genomic View
Cytogenetic band: 7q11.23 by HGNC 7q11.23 by Entrez Gene 7q11.23 by Ensembl
YWHAG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
General Annotation


Sub Unit:
Homodimer. Interacts with SAMSN1 (By similarity). Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT and SIRT2.Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509).


Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.


Subcellular Location:
Cytoplasm


This product has not yet been referenced specifically in any publications.
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[1].
"Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23."

[2].
"14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells."

[3].
"De Novo Mutations in YWHAG Cause Early-Onset Epilepsy."

[4].
"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."

[5].
"Centrosome-related genes, genetic variation, and risk of breast cancer."

[6].
"Genome-wide association study of severity in multiple sclerosis."

[7].
"SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner."

[8].
"Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."

[9].
"Reduced expression of 14-3-3 gamma in uterine leiomyoma as identified by proteomics."

[10].
"14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation."
Sample Data
Sample Data
Sample Data
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