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Home  >  Protein  >  Human RYR2 Recombinant Protein
RYR2 (GeneName), Ryanodine receptor 2 (ProteinName), 10709_EIAAB.
Product Name:

Human RYR2/ Ryanodine receptor 2 Recombinant Protein

 
Cat.#:

R1387-1h

Brand:
EIAab®
Regulatory Status:
Alternative:

RYR-2,Cardiac muscle ryanodine receptor,Cardiac muscle ryanodine receptor-calcium release channel,Type 2 ryanodine receptor

Source:
E.coli
Species:
Human
Tags:
His
Purity:
>90% by SDS-PAGE
Concentration:
Reconstitution Dependent
Form:
Liquid
Storage Buffer:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Storage:
Store at -20°C. (Avoid repeated freezing and thawing.)
Research Area:
-
Human RYR2 Protein
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Human RYR2 Protein
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Product Datasheets
Instruction:
MSDS:


R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
General Annotation


Sub Unit:
Homotetramer. Can also form heterotetramers with RYR1 and RYR3 (By similarity). Interacts with FKBP1A and FKBP1B; these interactions may stabilize the channel in its closed state and prevent Ca(2+) leaks. Interacts with CALM and S100A1; these interactions regulate channel activity. Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with FKBP1B, PKA, PP1 and PP2A. Interacts with SELENON.


Function:
Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.


Subcellular Location:
Sarcoplasmic reticulum membrane Multi-pass membrane protein Membrane Multi-pass membrane protein Sarcoplasmic reticulum The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic.


This product has not yet been referenced specifically in any publications.
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