ESR1 (基因名), Estrogen receptor (蛋白名), 10707_EIAAB.
Human ESR1/ Estrogen receptor Recombinant Protein
ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1, ER, ESR, NR3A1
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Binds DNA as a homodimer. Can form a heterodimer with ESR2. Isoform 3 can probably homodimerize or heterodimerize with isoform 1 and ESR2. Interacts with FOXC2, MAP1S, SLC30A9, UBE1C and NCOA3 coactivator (By similarity). Interacts with EP300; the interaction is estrogen-dependent and enhanced by CITED1. Interacts with CITED1; the interaction is estrogen-dependent. Interacts with NCOA5 and NCOA6 coactivators. Interacts with NCOA7; the interaction is a ligand-inducible. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2, FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with KMT2D/MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol. Interacts with KIF18A and LDB1. Interacts with RLIM (via C-terminus). Interacts with MACROD1. Interacts with SH2D4A and PLCG. Interaction with SH2D4A blocks binding to PLCG and inhibits estrogen-induced cell proliferation. Interacts with DYNLL1. Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes. Interacts with NR2C1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth. Interacts with DYX1C1. Interacts with PRMT2. Interacts with PI3KR1 or PI3KR2, SRC and PTK2/FAK1. Interacts with RBFOX2. Interacts with STK3/MST2 only in the presence of SAV1 and vice-versa. Binds to CSNK1D. Interacts with NCOA2; NCOA2 can interact with ESR1 AF-1 and AF-2 domains simultaneously and mediate their transcriptional synergy. Interacts with DDX5. Interacts with NCOA1; the interaction seems to require a self-association of N-terminal and C-terminal regions. Interacts with ZNF366, DDX17, NFKB1, RELA, SP1 and SP3. Interacts with NRIP1 (By similarity). Interacts with GPER1; the interaction occurs in an estrogen-dependent manner. Interacts with CLOCK and the interaction is stimulated by estrogen. Interacts with BCAS3. Interacts with TRIP4 (ufmylated); estrogen dependent. Interacts with LMTK3; the interaction phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner. Interacts with ZFHX3. Interacts with SFR1 in a ligand-dependent and -independent manner (PubMed:23874500). Interacts with DCAF13, LATS1 and VPRBP; regulates ESR1 ubiquitination and ubiquitin-mediated proteasomal degradation (PubMed:28068668). Interacts (via DNA-binding domain) with POU4F2 (C-terminus); this interaction increases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner.
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.
Nucleus Golgi apparatus Cell membrane Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated.
MTMTLHTKAS | GMALLHQIQG | NELEPLNRPQ | LKIPLERPLG | EVYLDSSKPA |
VYNYPEGAAY | EFNAAAAANA | QVYGQTGLPY | GPGSEAAAFG | SNGLGGFPPL |
NSVSPSPLML | LHPPPQLSPF | LQPHGQQVPY | YLENEPSGYT | VREAGPPAFY |
RPNSDNRRQG | GRERLASTND | KGSMAMESAK | ETRYCAVCND | YASGYHYGVW |
SCEGCKAFFK | RSIQGHNDYM | CPATNQCTID | KNRRKSCQAC | RLRKCYEVGM |
MKGGIRKDRR | GGRMLKHKRQ | RDDGEGRGEV | GSAGDMRAAN | LWPSPLMIKR |
SKKNSLALSL | TADQMVSALL | DAEPPILYSE | YDPTRPFSEA | SMMGLLTNLA |
DRELVHMINW | AKRVPGFVDL | TLHDQVHLLE | CAWLEILMIG | LVWRSMEHPG |
KLLFAPNLLL | DRNQGKCVEG | MVEIFDMLLA | TSSRFRMMNL | QGEEFVCLKS |
IILLNSGVYT | FLSSTLKSLE | EKDHIHRVLD | KITDTLIHLM | AKAGLTLQQQ |
HQRLAQLLLI | LSHIRHMSNK | GMEHLYSMKC | KNVVPLYDLL | LEMLDAHRLH |
APTSRGGASV | EETDQSHLAT | AGSTSSHSLQ | KYYITGEAEG | FPATV
"Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia."
"Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women."
"Role of genetic polymorphism of estrogen receptor-alpha gene and risk of prostate cancer in north Indian population."
"Alleles and haplotypes of the estrogen receptor alpha gene are associated with an increased risk of spontaneous abortion."
"Association between ESR1 and ESR2 gene polymorphisms and hyperlipidemia in Chinese Han postmenopausal women."
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