NMU (GeneName), Neuromedin-U (ProteinName), 10703_EIAAB.
Human NMU/ Neuromedin-U Recombinant Protein
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
R&D Technical Data
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Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.
MLRTESCRPR | SPAGQVAAAS | PLLLLLLLLA | WCAGACRGAP | ILPQGLQPEQ |
QLQLWNEIDD | TCSSFLSIDS | QPQASNALEE | LCFMIMGMLP | KPQEQDEKDN |
TKRFLFHYSK | TQKLGKSNVV | SSVVHPLLQL | VPHLHERRMK | RFRVDEEFQS |
PFASQSRGYF | LFRPRNGRRS | AGFI
This product has not yet been referenced specifically in any publications.
"Cloning and characterization of the cDNA encoding the human neuromedin U (NmU) precursor: NmU expression in the human gastrointestinal tract."
"Association between neuromedin U gene variants and overweight and obesity."
"Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway."
"Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S."
"Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia."
"The neuromedin U-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer."
"Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias."
"Signaling and ligand binding by recombinant neuromedin U receptors: evidence for dual coupling to Galphaq/11 and Galphai and an irreversible ligand-receptor interaction."
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