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Home  >  Protein  >  Human GPC1 Recombinant Protein
GPC1 (GeneName), Glypican-1 (ProteinName), 10702_EIAAB.
Product Name:

Human GPC1/ Glypican-1 Recombinant Protein

 
Cat.#:

R9038-1h

Brand:
EIAab®
Regulatory Status:
Source:
E.coli
Species:
Human
Tags:
His
Purity:
>90% by SDS-PAGE
Concentration:
Reconstitution Dependent
Form:
Liquid
Storage Buffer:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Storage:
Store at -20°C. (Avoid repeated freezing and thawing.)
Research Area:
-
Human GPC1 Protein
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Human GPC1 Protein
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Product Datasheets
Instruction:
MSDS:


R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Genomic View
Cytogenetic band: 2q37.3 by HGNC 2q37.3 by Entrez Gene 2q37.3 by Ensembl
GPC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
General Annotation


Sub Unit:
N/A


Function:
Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.


Subcellular Location:
Secreted glypican-1 Secreted Extracellular space


This product has not yet been referenced specifically in any publications.
Publishing research using this product ?
Please let us know and we will provide a credit for your next order.

[1].
"Crystal structure of N-glycosylated human glypican-1 core protein: structure of two loops evolutionarily conserved in vertebrate glypican-1."

[2].
"The structural role of N-linked glycans on human glypican-1."

[3].
"Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women."

[4].
"S-Nitrosylation of secreted recombinant human glypican-1."

[5].
"A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype."

[6].
"Correlation of glypican-1 expression with TGF-beta, BMP, and activin receptors in pancreatic ductal adenocarcinoma."

[7].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[8].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[9].
"Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease."

[10].
"Glypican-1 is a vehicle for polyamine uptake in mammalian cells: a pivital role for nitrosothiol-derived nitric oxide."
Sample Data
Sample Data
Sample Data
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