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Opi (Shorten Name),
Product Name:

Human Opi/ Opiorphin Recombinant Protein

 
Cat.#:

R1779h

Brand:
EIAab®
Regulatory Status:
Source:
E.coli
Species:
Human
Tags:
His
Purity:
>90% by SDS-PAGE
Concentration:
Reconstitution Dependent
Form:
Liquid
Storage Buffer:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Storage:
Store at -20°C. (Avoid repeated freezing and thawing.)
Research Area:
-
Human Opi Protein
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Human Opi Protein
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Product Datasheets
Instruction:
MSDS:


R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
General Annotation


Sub Unit:
N/A


Function:
Opiorphin is an endogenous chemical compound first isolated from human saliva. Initial research with mice shows the compound has a painkilling effect greater than that of morphine. It works by stopping the normal breakdown of enkephalins, natural pain-killing opioids in the spinal cord. It is a relatively simple molecule consisting of a five-amino acid polypeptide, Gln-Arg-Phe-Ser-Arg. Opiorphin pentapeptide originates from the N-terminal region of the protein PROL1 (proline rich, lacrimal 1). Opiorphin inhibits three proteases: neutral ecto-endopeptidase (MME), ecto-aminopeptidase N (ANPEP) and perhaps also a dipeptidyl peptidase DPP3. Such action extends the duration of enkephalin effect where the natural pain killers are released physiologically in response to specific potentially painful stimuli, in contrast with administration of narcotics, which floods the entire body and causes many undesirable adverse reactions, including addiction liability and constipation. In addition, opiorphin may exert anti-depressive action.


Location:
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This product has not yet been referenced specifically in any publications.
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