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ATM (基因名), Serine-protein kinase ATM (蛋白名), atm_human.

产品名称:

ATM Antibody

货号:

P1361Rb

商标:

EIAab^®

监管等级:

RUO

别名:

Ataxia telangiectasia mutated, A-T mutated

序列号:

Q13315

反应性:

human, mouse

免疫原:

corresponding to a sequence mapping at the 2686-2998aa of Q13315

形态:

Liquid

存储说明:

4℃ for frequent use, -20℃ to -70℃ for 6 months

缓冲液:

0.1M×PBS,50% glycerol,pH7.5

浓度:

200ug/ml

纯化方式:

Immunogen affinity purified

克隆性:

Polyclonal

亚型:

Rabbit IgG

应用:

推荐产品:

Goat Anti-Rabbit IgG(H+L) HRP-conjugated Antibody

研究领域:

Cancer

规格 & 价格:

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Human ATM Polyclonal Antibody

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产品说明书

数据表:

MSDS:

在线询价

数据
文献
序列 / 3D
常见问题解答
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R&D 技术数据

Western Blot - A.NT2D1 whole cell lysate/extract 5% SDS-PAGE, antibody dilution 1:1000.

Human Kidney (formalin-fixed, paraffin-embedded) stained with ATM antibody at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

通用注释

亚单元:

Dimers or tetramers in inactive state. On DNA damage, autophosphorylation dissociates ATM into monomers rendering them catalytically active. Binds p53/TP53, ABL1, BRCA1, NBN/nibrin and TERF1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with RAD17; DNA damage promotes the association. Interacts with EEF1E1; the interaction, induced on DNA damage, up-regulates TP53. Interacts with DCLRE1C, KAT8, KAT5, NABP2, ATMIN and CEP164. Interacts with AP2B1 and AP3B2; the interaction occurs in cytoplasmic vesicles (By similarity). Interacts with TELO2 and TTI1. Interacts with DDX1. Interacts with BRAT1.

功能:

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.

亚细胞位置:

Nucleus Cytoplasmic vesicle Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin.

数据库链接

UniGene:

Hs.367437

STRING:

9606.ENSP00000278616

KEGG:

hsa:472

MIM:

208900

Pfam:

PF02259

Uniprot:

Q13315

相关产品

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该产品尚未在任何出版物中被引用。

[1].

多克隆抗体ATM可以申请产品的免费试用装吗？

我们不提供作测试目的的免费样品或试用装样品。如果某种抗体的性能与说明书上的数据说明不同，我们将提供换货或退款服务。如果抗体用于未测试的物种或应用，我们不提供换货或退款服务。EIAab产品的投诉期为6个月，逾期不予受理。

[2].

多克隆抗体ATM说明书上的信息是及时更新的吗？

说明书包含了我们能获得的关于该产品的最新信息。当我们获得另外的信息时，说明书会实时更新，因此说明书绝不会过时。

[3].

如何选择合适的一抗？

请先确定您要检测的种属和使用的实验方法，然后查找相关产品，根据说明书上描述的“种属和应用”来确定合适的抗体。如果说明书中有明确您要检测的种属和实验方法均经过检测，则您可以放心地购买该产品。

[4].

多克隆抗体ATM在其他物种或应用中测试过吗？

所有我们测试过抗体的物种和应用都会在说明书上说明。我们获取新信息后，就会立即更新物种和应用。

[5].

如何保存多克隆抗体ATM？

我们建议始终按照说明书上的方法保存抗体。如果没有按照说明书上的说明保存，我们不能保证抗体的性能。

[6].

如何分装多克隆抗体ATM？

请根据一次实验的常用量进行分装。每等份不应少于10μl；每等份的量越少，抗体储液浓度受蒸发和管壁吸附的影响越大。

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