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Rraga (GeneName), Ras-related GTP-binding protein A (ProteinName), rraga_mouse.
Product Name:

Mouse Rraga/ Ras-related GTP-binding protein A ELISA Kit

 
Cat.#:

E3277m

Brand:
EIAab®
Regulatory Status:
Alternative:

Rag A

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.312-20ng/mL
Sensitivity:
0.099ng/mL
Specificity:
Natural and recombinant mouse Ras-related GTP-binding protein A
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Research Area:
Cancer
Product Overview:
E3277m is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin and Metalloprotease 30 (Ras-related GTP-binding protein A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Ras-related GTP-binding protein A. The ELISA analytical biochemical technique of the E3277m kit is based on Ras-related GTP-binding protein A antibody-Ras-related GTP-binding protein A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Ras-related GTP-binding protein A antigen targets in samples. The ELISA Kit is designed to detect native, recombinant, Ras-related GTP-binding protein A. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Mouse Rraga ELISA Kit
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Product Datasheets
Datasheet:
Instruction:
MSDS:


General Annotation


Sub Unit:
Can occur as a homodimer or as a heterodimer with RRAGC or RRAGD in a sequence-independent manner; heterodimerization stabilizes proteins of the heterodimer. In complex with RRAGC, but not with RRAGB, interacts with RPTOR. The GTP-bound form of RRAGA interacts with NOL8. Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGA and is negatively regulated by amino acids. The Rag heterodimer interacts with SLC38A9; the probable amino acid sensor. Interacts (inactive GDP-bound form) with RNF152; stimulated by amino acid starvation. Interacts (polyubiquitinated) with the GATOR1 complex; inactivates RRAGA. Interacts (polyubiquitinated) with TSC2 (By similarity). Interacts with SESN1, SESN2 AND SESN3 (PubMed:25259925).


Function:
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death.


Subcellular Location:
Cytoplasm Nucleus Lysosome Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state (By similarity).


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