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Home  >  ELISA Kit  >  Human C19orf80 ELISA Kit
C19orf80 (GeneName), Betatrophin (ProteinName), betat_human.
Product Name:

Human C19orf80/ Betatrophin ELISA Kit

 
Cat.#:

E11644h

Brand:
EIAab®
Regulatory Status:
RUO
Alternative:

Angiopoietin-like protein 8,Lipasin,Angptl8,UNQ599/PRO1185

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
78-5000pg/mL
Sensitivity:
32pg/ml
Specificity:
Natural and recombinant human Betatrophin
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Sign in.
Assay Procedure:
Research Area:
Immunology
Product Overview:
E11644h is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin and Metalloprotease 30 (Betatrophin) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Betatrophin. The ELISA analytical biochemical technique of the E11644h kit is based on Betatrophin antibody-Betatrophin antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Betatrophin antigen targets in samples. The ELISA Kit is designed to detect native, recombinant, Betatrophin. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Human C19orf80 ELISA Kit
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Human C19orf80 ELISA Kit
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Product Datasheets
Datasheet:
Instruction:
MSDS:


Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤≤6.5%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤≤9.2%

Recovery
Recovery was determined by spiking various levels of Betatrophin into serum and plasma.

Sample Type

Average(%)

Recovery Range(%)

Serum

101

95-107

Plasma

103

97-109

 

 

 

 

Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Betatrophin and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample

1：2

1:4

1:8

1:16

serum(n=5)

95-107%

86-99%

97-107%

87-96%

EDTA plasma(n=5)

96-106%

91-100%

102-112%

90-100%

heparin plasma(n=5)

92-102%

 

103-113%

86-96%

83-93%

 

General Annotation


Sub Unit:
Interacts with ANGPTL3.


Function:
Hormone that specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. Promotes pancreatic beta cell proliferation without insulin resistance. Also acts as a blood lipid regulator by regulating serum triglyceride levels; possibly by promoting ANGPTL3 cleavage.


Subcellular Location:
Secreted


Database links


Uniprot:
Q6UXH0
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[1].
"Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery"
Miriam E, Marianne B, Nuria V, et al.
From: Translational Research

[2].
"Possible proteolyzation of circulating betatrophin in human serum"
S. Tokumoto, Y. Hamamoto, E. Okamura, et al
From: Journal of Diabetes Investigation

[3].
"Circulating betatrophin is strongly increased in pregnancy and gestational diabetes mellitus"
Trebotic L K, Klimek P, Thomas A, et al
From: PloS one

[4].
"Increased ANGPTL3, 4 and ANGPTL8/betatrophin expression levels in obesity and T2D"
Abu-Farha M, Al-Khairi I, Cherian P, et al.
From: Lipids in Health and Disease

[5].
"Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes"
Daniel Espes, Joey Lau, Per-Ola Carlsson
From: Diabetologia

[6].
"Serum betatrophin level increased in subjects with metabolic syndrome: a case-control study"
Zhu J Z, Li C X, Dai Y N, et al
From: Nutrición Hospitalaria

[7].
"Relationship Between Angiopoietin-Like Protein 8 and Fasting Serum Triglyceride Level"
H Yamada, I Kusaka, R Saikawa, et al.
From: Journal of Clinical Medicine research

[8].
"Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals"
A Fenzl, BK Itariu, L Kosi, et al.
From: Diabetologia

[9].
"Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes"
D Espes, M Martinell, PO Carlsson
From: International journal of endocrinology

[10].
"Increased Circulating Levels of Betatrophin in Newly Diagnosed Type 2 Diabetic Patients"
H Hu, W Sun, S Yu, et al.
From: Diabetes Care

[11].
"Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity"
Z Fu, F Berhane, A Fite, et al.
From: Scientific Reports

[12].
"An explanation for recent discrepancies in levels of human circulating betatrophin"
Z Fu, AB Abou-Samra, R Zhang
From: Diabetologia

[13].
"Characterisation of betatrophin concentrations in childhood and adolescent obesity and insulin resistance"
S Wu, H Gao, Y Ma, et al.
From: Pediatric Diabetes

[14].
"Increased levels of irisin in people with long-standing Type 1 diabetes"
D Espes, J Lau, PO Carlsson
From: Diabetic Medicine

[15].
"Correlation of circulating betatrophin concentrations with insulin secretion capacity, evaluated by glucagon stimulation test"
S Tokumoto, Y Hamamoto, K Fujimoto, et al.
From: Diabetes Medicine

[16].
"betatrophin in Diabetes Mellitus: the Epidemiological Evidence in Humans"
D Espes, M Martinell, H Liljebäck, PO Carlsson
From: Current Diabetes Reports

[17].
"Circulating betatrophin in patients with type 2 diabetes: a meta-analysis"
Li S, Liu D, Li L, et al.
From: Journal of diabetes research

[18].
"Circulating angiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolic syndrome"
Abu-Farha M, Abubaker J, Al-Khairi I, et al.
From: Cardiovascular Diabetology

[19].
"Circulating ANGPTL8/betatrophin is increased in obesity and reduced after exercise training"
Abu-Farha M, Sriraman D, Cherian P, et al.
From: PloS one

[20].
"Circulating Betatrophin Is Increased in Patients with Overt and Subclinical Hypothyroidism"
Han C, Xia X, Liu A, et al.
From: BioMed research international

[21].
"Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes"
H Yamada, T Saito, A Aoki, et al.
From: Endocrine journal

[22].
"Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance"
X Xie, T Gao, M Yang, et al.
From: Diabetology & metabolic syndrome

[23].
"Altered Concentrations in Dyslipidemia Evidence a Role for ANGPTL8/Betatrophin in Lipid Metabolism in Humans"
Gómez-Ambrosi J, Pascual-Corrales E, Catalán V, et al.
From: The Journal of Clinical Endocrinology & Metabolism

[24].
"Vitamin D modifies the associations between circulating betatrophin and cardiometabolic risk factors among youths at risk for metabolic syndrome"
Fu J, Hou C, Li L, et al.
From: Cardiovascular Diabetology

[25].
"Increased angiopoietin-like protein 8 levels in patients with type 2 diabetes and cardiovascular disease"
Huang Y, Fang C, Guo H, et al.
From: Diabetes Research and Clinical Practice

[26].
"Circulating betatrophin in pregnant individuals with gestational diabetes mellitus and normal glucose tolerance"
Zheng D, Cui C, Yu M, et al.
From: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE

[27].
"ANGPTL8 as a new determinant of type 2 diabetes remission after bariatric surgery"
M Ejarque, M Borlaug, N Vilarrasa, et al.
From: Translational Research

[28].
"Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreatic β-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus ..."
L Wang, J Song, C Wang, et al.
From: Journal of Diabetes Research

[29].
"Relationship of betatrophin with youth onset type 2 diabetes among Asian Indians"
K Gokulakrishnan, K Manokaran, GK Pandey, et al.
From: Diabetes Research and Clinical Practice

[30].
"Decreased circulating levels of ANGPTL8 in Graves’ disease patients"
HX Li, MJ Xu, L Zhao, et al.
From: Hormones-International Journal of Endocrinology and Metabolism

[31].
"AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells"
Lee J, Hong SW, Park SE, et al.
From: Molecular and Cellular Endocrinology

[32].
"Positive Association Between Betatrophin and Diabetic Retinopathy Risk in Type 2 Diabetes Patients"
Wang Y Y, Zhang D, Jiang Z Y, et al.
From: Hormone and Metabolic Research

[33].
"Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: A brown adipose tissue-derived endocrine factor with a potential role in fetal growth"
Martinez-Perez B, Ejarque M, Gutierrez C, et al.
From: Translational Research

[34].
"ANGPTL8/Betatrophin R59W variant is associated with higher glucose level in non-diabetic Arabs living in Kuwaits"
Abu-Farha M, Melhem M, Abubaker J, et al.
From: Lipids in health and disease

[35].
"Betatrophin Levels were Increased in Pregnant Women with or without Gestational Diabetes Mellitus and Associated with Beta Cell Function"
Huang Y, Fang C, Ma Z, et al.
From: Rev Bras Ginecol Obstet

[36].
"Circulating angiopoietin-like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children"
Chung H S, Lee M J, Hwang S Y, et al.
From: Cardiovascular diabetology

[37].
"Circulating Betatrophin in Healthy Control and Type 2 Diabetic Subjects and its Association with Metabolic Parameters"
Al-Daghri N M, Rahman S, Sabico S, et al.
From: Journal of Diabetes and its Complications

[38].
"Circulating betatrophin levels are increased in patients with type 2 diabetes and associated with insulin resistance"
Chen X, Lu P, He W, et al
From: J Clin Endocrinol Metab.

[39].
"Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function"
Chen C C, Susanto H, Chuang W H, et al.
From: Cardiovascular diabetology

[40].
"Increased Cord Blood Betatrophin Levels in the Offspring of Mothers with Gestational Diabetes"
Xie X, Gao H, Wu S, et al.
From: PloS one

[41].
"Lipasin, a biomarker of diabetic retinopathy"
Fang C, Huang Y, Guo H, et al.
From: Diabetes research and clinical practice

[42].
"Increased serum levels of betatrophin in pancreatic cancer-associated diabetes"
Susanto H, Liu T Y, Chen C C
From: Oncotarget

[43].
"The Arg59Trp variant in ANGPTL8 (betatrophin) is associated with total and HDL-cholesterol in American Indians and Mexican Americans and ..."
Hanson R L, Leti F, Tsinajinnie D, et al.
From: Molecular genetics and metabolism

[44].
"Betatrophin Acts as a Diagnostic Biomarker in Type 2 Diabetes Mellitus and Is Negatively Associated with HDL-Cholesterol"
Yi M, Chen R, Yang R, et al.
From: International journal of endocrinology

[45].
"Circulating betatrophin correlates with triglycerides and postprandial glucose among different glucose tolerance statuses—a case-control study"
Gao T, Jin K, Chen P, et al.
From: PloS one

[46].
"Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance"
Abu-Farha M, Abubaker J, Noronha F
From: scientific reports

[47].
"Irisin 与 betatrophin 的关系以及对 β 细胞增殖作用的研究"
谢心苗
From: 南方医科大学

[48].
"Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects"
Abu-Farha M, Abubaker J, Noronha F, et al
From: Cardiovascular diabetology

[49].
"Weight loss partially restores glucose-driven betatrophin response in humans"
Maurer L, Brachs S, Decker A M, et al.
From: The Journal of Clinical Endocrinology & Metabolism

[50].
"Plasma Betatrophin Levels of Subjects Classified with Normal,Impaired, and Diabetic Glucose Tolerance, and Subjects withImpaired Fasting Glucose"
Sibel O, Burak O, Eda Merve K, et al.
From: Hormone and Metabolic Research

[51].
"ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives"
Christian von L, Andreas F. H. Pfeiffer, Johan F. L, et al.
From: Hormone and Metabolic Research

[52].
"Insulin upregulates betatrophin expression via PI4K/Akt pathway"
Puhan L, Xi C, Zeqing Z, et al.
From: Scientific Reports

[53].
"Sustained spontaneous partial remission in a pediatric patient with type 1 diabetes"
M Murillo, M Fonolleda, L Bosch, et al.
From: Journal of Clinical and Translational Endocrinology: Case Reports

[54].
"Angiopoietin-like protein 8: an attractive biomarker for the evaluation of subjects with insulin resistance and related disorders"
S Wang, XF Hong, ZG Tu, et al.
From: Diabetes Research and Clinical Practice

[55].
"Angiopoietin-like protein 8 in early pregnancy improves the prediction of gestational diabetes"
Y Huang, X Chen, XH Chen, et al.
From: Diabetologia

[56].
"The Correlation Between Circulating Betatrophin and Insulin Resistance in General Population: A Meta-Analysis"
JL Xu, YY Lin, H Zhou, et al.
From: Hormone and Metabolic Research

[57].
"Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China"
TP Zheng, B Ge, HB Liu, et al.
From: Cardiovascular Diabetology

[58].
"Angiopoietin-like 8 (ANGPTL8) expression is regulated by miR-143-3p in human hepatocytes"
J K. DiStefano
From: Gene

[59].
"The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity"
MD Luo, ZY Zhang, S Wang, et al.
From: Cardiovascular Diabetology

[60].
"Angiopoietin-like protein 8/betatrophin correlates with hepatocellular lipid content independent of insulin resistance in non-alcoholic fatty liver disease patients"
B S Hong, J Liu, J Zheng, et al.
From: Journal of Diabetes Investigation

[61].
"Increased plasma and adipose tissue levels of ANGPTL8/Betatrophin and ANGPTL4 in people with hypertension"
M Abu-Farha, P Cherian, D Sriraman, et al.
From: Lipids in Health and Disease

[62].
"Biphasic changes in angiopoietin-like 8 level after laparoscopic sleeve gastrectomy and type 2 diabetes remission during a 1-year follow-up"
E Al-Shawaf, J Tuomilehto, H Arefanian, et al.
From: Surgery for Obesity and Related Diseases

[63].
"ANGPTL8 (betatrophin) role in diabetes and metabolic diseases"
M Abu-Farha, J Abubaker, J Tuomilehto.
From: Diabetes/Metabolism Research and Reviews

[64].
"ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ"
Y Zhang, X Guo, Y Chen, et al.
From: NATURE COMMUNICATIONS

[65].
"Apolipoprotein CIII may mediate the impacts of angiopoietin-like protein 8 on triglyceride metabolism"
M Luo, X Su, Y Yang, et al.
From: Lipids in Health and Disease

[66].
"Partial remission and early stages of pediatric type 1 diabetes display immunoregulatory changes. A pilot study"
A Villalba, M Fonolleda, M Murillo, et al.
From: Translational Research

[67].
"Circulating betatrophin/ANGPTL8 levels correlate with body fat distribution in individuals with normal glucose tolerance but not those with glucose disorders"
J Zheng, J Liu, B S. Hong, et al.
From: BMC Endocrine Disorders
Sample Data
Sample Data
Sample Data

3D Model:


B2m (119)

MARSVTLVFL
VLVSLTGLYA
IQKTPQIQVY
SRHPPENGKP
NILNCYVTQF
HPPHIEIQML
KNGKKIPKVE
MSDMSFSKDW
SFYILAHTEF
TPTETDTYAC
RVKHASMAEP
KTVYWDRDM
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