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首页  >  酶联免疫试剂盒  >  Human C19orf80 ELISA Kit
C19orf80 (基因名), Betatrophin (蛋白名), betat_human.
产品名称:

Human C19orf80/ Betatrophin ELISA Kit
Betatrophin

货号:

E11644h

商标:
EIAab®
监管等级:
RUO
别名:

Angiopoietin-like protein 8, Lipasin, UNQ599/PRO1185, Angptl8

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
78-5000pg/mL
灵敏度:
32pg/ml
特异性:
Natural and recombinant human Betatrophin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
登录.
实验步骤:
实验步骤
研究领域:
Immunology
Human C19orf80 ELISA Kit
规格 & 价格: cart
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Human C19orf80 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


精密度
批内差：已知浓度的3个样本在一个板子内重复检测20次，以评估批内精密度。
批内 CV： le;≤6.5%
批间差：已知浓度的3个样本在不同的板子上重复测定5次，以评估测定批间精密度。
批间 CV： le;≤9.2%
回收率
回收率：低、中和高浓度的分析物被掺入到血清或者血浆样本中，进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

101

95-107

Plasma

103

97-109

 

 

 

 

线性
线性：给定样本通过梯度稀释，每次稀释的测量值与理论值的比值。

Sample

1：2

1:4

1:8

1:16

serum(n=5)

95-107%

86-99%

97-107%

87-96%

EDTA plasma(n=5)

96-106%

91-100%

102-112%

90-100%

heparin plasma(n=5)

92-102%

 

103-113%

86-96%

83-93%

 

通用注释


亚单元:
Interacts with ANGPTL3.


功能:
Hormone that specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. Promotes pancreatic beta cell proliferation without insulin resistance. Also acts as a blood lipid regulator by regulating serum triglyceride levels; possibly by promoting ANGPTL3 cleavage.


亚细胞位置:
Secreted


数据库链接


Uniprot:
Q6UXH0
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arrows
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[1].
"Sustained spontaneous partial remission in a pediatric patient with type 1 diabetes"
M Murillo, M Fonolleda, L Bosch, et al.
From: Journal of Clinical and Translational Endocrinology: Case Reports

[2].
"ANGPTL8 negatively regulates NF-κB activation by facilitating selective autophagic degradation of IKKγ"
Y Zhang, X Guo, Y Chen, et al.
From: NATURE COMMUNICATIONS

[3].
"The Correlation Between Circulating Betatrophin and Insulin Resistance in General Population: A Meta-Analysis"
JL Xu, YY Lin, H Zhou, et al.
From: Hormone and Metabolic Research

[4].
"Biphasic changes in angiopoietin-like 8 level after laparoscopic sleeve gastrectomy and type 2 diabetes remission during a 1-year follow-up"
E Al-Shawaf, J Tuomilehto, H Arefanian, et al.
From: Surgery for Obesity and Related Diseases

[5].
"Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China"
TP Zheng, B Ge, HB Liu, et al.
From: Cardiovascular Diabetology

[6].
"The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity"
MD Luo, ZY Zhang, S Wang, et al.
From: Cardiovascular Diabetology

[7].
"Angiopoietin-like protein 8: an attractive biomarker for the evaluation of subjects with insulin resistance and related disorders"
S Wang, XF Hong, ZG Tu, et al.
From: Diabetes Research and Clinical Practice

[8].
"Angiopoietin-like 8 (ANGPTL8) expression is regulated by miR-143-3p in human hepatocytes"
J K. DiStefano
From: Gene

[9].
"Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study"
Xyu Meng, Hj Zou, Dp Li, et al.
From: ORIGINAL RESEARCH

[10].
"Angiopoietin-like protein 8 in early pregnancy improves the prediction of gestational diabetes"
Y Huang, X Chen, XH Chen, et al.
From: Diabetologia

[11].
"Relationship Between Angiopoietin-Like Protein 8 and Fasting Serum Triglyceride Level"
H Yamada, I Kusaka, R Saikawa, et al.
From: Journal of Clinical Medicine research

[12].
"Predictive values of ANGPTL8 on risk of all-cause mortality in diabetic patients: results from the REACTION Study"
Hj Zou, Yp Xu, X Chen, et al.
From: Cardiovascular Diabetology

[13].
"The multi-faces of Angptl8 in health and disease: Novel functions beyond lipoprotein lipase modulation"
M Abu-Farha, A Ghosh, I Al-Khairi, et al.
From: Progress in Lipid Research

[14].
"Circulating ANGPTL8 levels and risk of kidney function decline: Results from the 4C Study"
Hj Zou, Yp Xu, Xy Meng, et al.
From: Cardiovascular Diabetology

[15].
"The circulating ANGPTL8 levels show differences among novel subgroups of adult patients with diabetes and are associated with mortality in the subsequent 5 years"
Hj Zou, W Duan, Zq Zhang, et al.
From: Scientific Reports

[16].
"Decreased circulating levels of ANGPTL8 in Graves’ disease patients"
HX Li, MJ Xu, L Zhao, et al.
From: Hormones-International Journal of Endocrinology and Metabolism

[17].
"Partial remission and early stages of pediatric type 1 diabetes display immunoregulatory changes. A pilot study"
A Villalba, M Fonolleda, M Murillo, et al.
From: Translational Research

[18].
"New insights into ANGPTL8 in modulating the development of cardio-metabolic disorder diseases"
X Su, Gm Zhang, Y Cheng, et al.
From: Molecular Biology Reports

[19].
"Angiopoietin-like protein 8/betatrophin correlates with hepatocellular lipid content independent of insulin resistance in non-alcoholic fatty liver disease patients"
B S Hong, J Liu, J Zheng, et al.
From: Journal of Diabetes Investigation

[20].
"ANGPTL8 (betatrophin) role in diabetes and metabolic diseases"
M Abu-Farha, J Abubaker, J Tuomilehto.
From: Diabetes/Metabolism Research and Reviews

[21].
"Apolipoprotein CIII may mediate the impacts of angiopoietin-like protein 8 on triglyceride metabolism"
M Luo, X Su, Y Yang, et al.
From: Lipids in Health and Disease

[22].
"Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes"
Daniel Espes, Joey Lau, Per-Ola Carlsson
From: Diabetologia

[23].
"Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals"
A Fenzl, BK Itariu, L Kosi, et al.
From: Diabetologia

[24].
"Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes"
D Espes, M Martinell, PO Carlsson
From: International journal of endocrinology

[25].
"Increased Circulating Levels of Betatrophin in Newly Diagnosed Type 2 Diabetic Patients"
H Hu, W Sun, S Yu, et al.
From: Diabetes Care

[26].
"Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity"
Z Fu, F Berhane, A Fite, et al.
From: Scientific Reports

[27].
"An explanation for recent discrepancies in levels of human circulating betatrophin"
Z Fu, AB Abou-Samra, R Zhang
From: Diabetologia

[28].
"Characterisation of betatrophin concentrations in childhood and adolescent obesity and insulin resistance"
S Wu, H Gao, Y Ma, et al.
From: Pediatric Diabetes

[29].
"Correlation of circulating betatrophin concentrations with insulin secretion capacity, evaluated by glucagon stimulation test"
S Tokumoto, Y Hamamoto, K Fujimoto, et al.
From: Diabetes Medicine

[30].
"Increased levels of irisin in people with long-standing Type 1 diabetes"
D Espes, J Lau, PO Carlsson
From: Diabetic Medicine

[31].
"Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes"
H Yamada, T Saito, A Aoki, et al.
From: Endocrine journal

[32].
"Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance"
X Xie, T Gao, M Yang, et al.
From: Diabetology & metabolic syndrome

[33].
"Circulating Levels of Betatrophin and Irisin Are Not Associated with Pancreatic β-Cell Function in Previously Diagnosed Type 2 Diabetes Mellitus ..."
L Wang, J Song, C Wang, et al.
From: Journal of Diabetes Research

[34].
"Relationship of betatrophin with youth onset type 2 diabetes among Asian Indians"
K Gokulakrishnan, K Manokaran, GK Pandey, et al.
From: Diabetes Research and Clinical Practice

[35].
"AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells"
Lee J, Hong SW, Park SE, et al.
From: Molecular and Cellular Endocrinology

[36].
"Angiopoietin-like protein 8 (ANGPTL8) in pregnancy: A brown adipose tissue-derived endocrine factor with a potential role in fetal growth"
Martinez-Perez B, Ejarque M, Gutierrez C, et al.
From: Translational Research

[37].
"ANGPTL8/Betatrophin R59W variant is associated with higher glucose level in non-diabetic Arabs living in Kuwaits"
Abu-Farha M, Melhem M, Abubaker J, et al.
From: Lipids in health and disease

[38].
"Betatrophin Levels were Increased in Pregnant Women with or without Gestational Diabetes Mellitus and Associated with Beta Cell Function"
Huang Y, Fang C, Ma Z, et al.
From: Rev Bras Ginecol Obstet

[39].
"Circulating angiopoietin-like protein 8 (ANGPTL8) and ANGPTL3 concentrations in relation to anthropometric and metabolic profiles in Korean children"
Chung H S, Lee M J, Hwang S Y, et al.
From: Cardiovascular diabetology

[40].
"Circulating angiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolic syndrome"
Abu-Farha M, Abubaker J, Al-Khairi I, et al.
From: Cardiovascular Diabetology

[41].
"Circulating ANGPTL8/betatrophin is increased in obesity and reduced after exercise training"
Abu-Farha M, Sriraman D, Cherian P, et al.
From: PloS one

[42].
"Circulating Betatrophin in Healthy Control and Type 2 Diabetic Subjects and its Association with Metabolic Parameters"
Al-Daghri N M, Rahman S, Sabico S, et al.
From: Journal of Diabetes and its Complications

[43].
"Circulating Betatrophin Is Increased in Patients with Overt and Subclinical Hypothyroidism"
Han C, Xia X, Liu A, et al.
From: BioMed research international

[44].
"Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function"
Chen C C, Susanto H, Chuang W H, et al.
From: Cardiovascular diabetology

[45].
"Increased Cord Blood Betatrophin Levels in the Offspring of Mothers with Gestational Diabetes"
Xie X, Gao H, Wu S, et al.
From: PloS one

[46].
"Lipasin, a biomarker of diabetic retinopathy"
Fang C, Huang Y, Guo H, et al.
From: Diabetes research and clinical practice

[47].
"Positive Association Between Betatrophin and Diabetic Retinopathy Risk in Type 2 Diabetes Patients"
Wang Y Y, Zhang D, Jiang Z Y, et al.
From: Hormone and Metabolic Research

[48].
"Possible proteolyzation of circulating betatrophin in human serum"
S. Tokumoto, Y. Hamamoto, E. Okamura, et al
From: Journal of Diabetes Investigation

[49].
"Serum betatrophin level increased in subjects with metabolic syndrome: a case-control study"
Zhu J Z, Li C X, Dai Y N, et al
From: Nutrición Hospitalaria

[50].
"The Arg59Trp variant in ANGPTL8 (betatrophin) is associated with total and HDL-cholesterol in American Indians and Mexican Americans and ..."
Hanson R L, Leti F, Tsinajinnie D, et al.
From: Molecular genetics and metabolism

[51].
"Betatrophin Acts as a Diagnostic Biomarker in Type 2 Diabetes Mellitus and Is Negatively Associated with HDL-Cholesterol"
Yi M, Chen R, Yang R, et al.
From: International journal of endocrinology

[52].
"betatrophin in Diabetes Mellitus: the Epidemiological Evidence in Humans"
D Espes, M Martinell, H Liljebäck, PO Carlsson
From: Current Diabetes Reports

[53].
"Circulating betatrophin correlates with triglycerides and postprandial glucose among different glucose tolerance statuses—a case-control study"
Gao T, Jin K, Chen P, et al.
From: PloS one

[54].
"Circulating betatrophin in patients with type 2 diabetes: a meta-analysis"
Li S, Liu D, Li L, et al.
From: Journal of diabetes research

[55].
"Circulating betatrophin is strongly increased in pregnancy and gestational diabetes mellitus"
Trebotic L K, Klimek P, Thomas A, et al
From: PloS one

[56].
"Circulating betatrophin levels are increased in patients with type 2 diabetes and associated with insulin resistance"
Chen X, Lu P, He W, et al
From: J Clin Endocrinol Metab.

[57].
"Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance"
Abu-Farha M, Abubaker J, Noronha F
From: scientific reports

[58].
"Irisin 与 betatrophin 的关系以及对 β 细胞增殖作用的研究"
谢心苗
From: 南方医科大学

[59].
"Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects"
Abu-Farha M, Abubaker J, Noronha F, et al
From: Cardiovascular diabetology

[60].
"Increased serum levels of betatrophin in pancreatic cancer-associated diabetes"
Susanto H, Liu T Y, Chen C C
From: Oncotarget

[61].
"Altered Concentrations in Dyslipidemia Evidence a Role for ANGPTL8/Betatrophin in Lipid Metabolism in Humans"
Gómez-Ambrosi J, Pascual-Corrales E, Catalán V, et al.
From: The Journal of Clinical Endocrinology & Metabolism

[62].
"Weight loss partially restores glucose-driven betatrophin response in humans"
Maurer L, Brachs S, Decker A M, et al.
From: The Journal of Clinical Endocrinology & Metabolism

[63].
"Vitamin D modifies the associations between circulating betatrophin and cardiometabolic risk factors among youths at risk for metabolic syndrome"
Fu J, Hou C, Li L, et al.
From: Cardiovascular Diabetology

[64].
"Increased angiopoietin-like protein 8 levels in patients with type 2 diabetes and cardiovascular disease"
Huang Y, Fang C, Guo H, et al.
From: Diabetes Research and Clinical Practice

[65].
"Circulating betatrophin in pregnant individuals with gestational diabetes mellitus and normal glucose tolerance"
Zheng D, Cui C, Yu M, et al.
From: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE

[66].
"Increased ANGPTL3, 4 and ANGPTL8/betatrophin expression levels in obesity and T2D"
Abu-Farha M, Al-Khairi I, Cherian P, et al.
From: Lipids in Health and Disease

[67].
"ANGPTL8 as a new determinant of type 2 diabetes remission after bariatric surgery"
M Ejarque, M Borlaug, N Vilarrasa, et al.
From: Translational Research

[68].
"Plasma Betatrophin Levels of Subjects Classified with Normal,Impaired, and Diabetic Glucose Tolerance, and Subjects withImpaired Fasting Glucose"
Sibel O, Burak O, Eda Merve K, et al.
From: Hormone and Metabolic Research

[69].
"ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives"
Christian von L, Andreas F. H. Pfeiffer, Johan F. L, et al.
From: Hormone and Metabolic Research

[70].
"Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery"
Miriam E, Marianne B, Nuria V, et al.
From: Translational Research

[71].
"Insulin upregulates betatrophin expression via PI4K/Akt pathway"
Puhan L, Xi C, Zeqing Z, et al.
From: Scientific Reports

[72].
"Increased plasma and adipose tissue levels of ANGPTL8/Betatrophin and ANGPTL4 in people with hypertension"
M Abu-Farha, P Cherian, D Sriraman, et al.
From: Lipids in Health and Disease

[73].
"Circulating betatrophin/ANGPTL8 levels correlate with body fat distribution in individuals with normal glucose tolerance but not those with glucose disorders"
J Zheng, J Liu, B S. Hong, et al.
From: BMC Endocrine Disorders
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3D 模型:


B2m (119)

MARSVTLVFL
VLVSLTGLYA
IQKTPQIQVY
SRHPPENGKP
NILNCYVTQF
HPPHIEIQML
KNGKKIPKVE
MSDMSFSKDW
SFYILAHTEF
TPTETDTYAC
RVKHASMAEP
KTVYWDRDM
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