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TXNIP (基因名), Thioredoxin-interacting protein (蛋白名), TXNIP_PIG.
产品名称:

Pig TXNIP/ Thioredoxin-interacting protein ELISA Kit
硫氧还蛋白相互作用蛋白

货号:

E1162p

商标:
EIAab®
监管等级:
检测方法:
ELISA
特异性:
Natural and recombinant pig Thioredoxin-interacting protein
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Pig TXNIP ELISA Kit
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Pig TXNIP ELISA Kit
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亚单元:
Homodimer; disulfide-linked. Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1 (By similarity). Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4.


功能:
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.


亚细胞位置:
Cytoplasm



[1].
Seok Kyo Seo, Hyo In Yang, Kyung Eun Lee, Hye Yeon Kim, SiHyun Cho, Young Sik Choi and Byung Seok Lee
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