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Sirpa (基因名), Tyrosine-protein phosphatase non-receptor type substrate 1 (蛋白名), SHPS1_MOUSE.
产品名称:

Mouse Sirpa/ Tyrosine-protein phosphatase non-receptor type substrate 1 ELISA Kit
SHPsubstrate1

货号:

E9001m

商标:
EIAab®
监管等级:
别名:

Brain Ig-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, Inhibitory receptor SHPS-1, MyD-1 antigen, Signal-regulatory protein alpha-1, p84, Bit, Sirp-alpha-1, CD172a, SHP substrate 1, Bit, Myd1, Ptpns1, Shps1, Sirp

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.156-10ng/mL
灵敏度:
0.082ng/mL
特异性:
Natural and recombinant mouse Tyrosine-protein phosphatase non-receptor type substrate 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Mouse Sirpa ELISA Kit
规格 & 价格: cart
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Mouse Sirpa ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B.


功能:
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.


亚细胞位置:
Membrane Single-pass type I membrane protein


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