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Mphosph8 (基因名), M-phase phosphoprotein 8 (蛋白名), MPP8_MOUSE.
产品名称:

Mouse Mphosph8/ M-phase phosphoprotein 8 ELISA Kit

货号:

E13455m

商标:
EIAab®
监管等级:
别名:

Mpp8

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
31.2-2000pg/mL
灵敏度:
16.3pg/mL
特异性:
Natural and recombinant mouse M-phase phosphoprotein 8
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Mouse Mphosph8 ELISA Kit
规格 & 价格: cart
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Mouse Mphosph8 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Homodimer. Interacts (via chromo domain) with histone H3K9me3. Has the highest affinity for H3K9me3, and lesser affinity for H3K9me2 and H3K9me1. Component of the HUSH complex; at least composed of FAM208A/TASOR, PPHLN1 and MPHOSPH8. Interacts with DNMT3, EHMT1 and SETDB1.


功能:
Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.


亚细胞位置:
Nucleus Chromosome Detected on heterochromatin (PubMed:23416073). Dissociates from chromatin during interphase and early mitosis (PubMed:23416073). Detected on nucleosomes (By similarity).


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