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首页  >  酶联免疫试剂盒  >  Mouse Morc2a ELISA Kit
Morc2a (基因名), ATPase MORC2A (蛋白名), MOR2A_MOUSE.
产品名称:

Mouse Morc2a/ ATPase MORC2A ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Kiaa0852, Zcwcc1, MORC family CW-type zinc finger protein 2A, Zinc finger CW-type coiled-coil domain protein 1

检测方法:
ELISA
特异性:
Natural and recombinant mouse ATPase MORC2A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Morc2a ELISA Kit
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Mouse Morc2a ELISA Kit
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产品说明书


通用注释


亚单元:
Homodimerizes upon ATP-binding and dissociate upon ATP hydrolysis; homodimerization is required for gene silencing (By similarity). Binds histone H3 independently of the methylation status at 'Lys-9' (PubMed:29728365). Interacts with HDAC4. Interacts with FAM208A/TASOR and MPHOSPH8; the interactions associate MORC2 with the HUSH complex which recruits MORC2 to heterochromatic loci (By similarity). Interacts with Morc2b (PubMed:29329290).


功能:
Essential for epigenetic silencing by the HUSH complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (By similarity). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark (PubMed:29728365). Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. During DNA damage response, regulates chromatin remodeling through ATP hydrolysis (By similarity). During DNA damage response, may regulate chromatin remodeling through ATP hydrolysis (By similarity).


亚细胞位置:
Nucleus Cytoplasm Cytosol Chromosome Nucleus matrix Mainly located in the nucleus. Upon phosphorylation at Ser-737, recruited to damaged chromatin.


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