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首页  >  酶联免疫试剂盒  >  Rat Mobkl1b ELISA Kit
Mobkl1b (基因名), Mps one binder kinase activator-like 1B (蛋白名), MOL1B_RAT.
产品名称:

Rat Mobkl1b/ Mps one binder kinase activator-like 1B ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Mob1 homolog 1B, Mobk1b

检测方法:
ELISA
特异性:
Natural and recombinant rat Mps one binder kinase activator-like 1B
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Rat Mobkl1b ELISA Kit
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Rat Mobkl1b ELISA Kit
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产品说明书


通用注释


亚单元:
Binds STK38 and STK38L. Interacts with LATS1 and LATS2 (By similarity). Forms a tripartite complex with STK38 and STK3/MST2.


功能:
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.


亚细胞位置:
N/A


该产品尚未在任何出版物中被引用。
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