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MOCS3 (基因名), Adenylyltransferase and sulfurtransferase MOCS3 (蛋白名), MOCS3_HUMAN.
产品名称:

Human MOCS3/ Adenylyltransferase and sulfurtransferase MOCS3 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Molybdenum cofactor synthesis protein 3, Molybdopterin synthase sulfurylase, MPT synthase sulfurylase, UBA4

检测方法:
ELISA
特异性:
Natural and recombinant human Adenylyltransferase and sulfurtransferase MOCS3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human MOCS3 ELISA Kit
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Human MOCS3 ELISA Kit
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通用注释


亚单元:
Interacts with NFS1.


功能:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.


亚细胞位置:
Cytoplasm


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