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MOB1B (基因名), MOB kinase activator 1B (蛋白名), MOB1B_HUMAN.
产品名称:

Human MOB1B/ MOB kinase activator 1B ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Mob1 homolog 1A, Mob1B, Mps one binder kinase activator-like 1A, Mob1A, MOB4A, MOBKL1A

检测方法:
ELISA
特异性:
Natural and recombinant human MOB kinase activator 1B
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Human MOB1B ELISA Kit
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Human MOB1B ELISA Kit
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产品说明书
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通用注释


亚单元:
Binds STK38L. Interacts with LATS1 and LATS2.


功能:
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.


亚细胞位置:
Cytoplasm Nucleus


该产品尚未在任何出版物中被引用。
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