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首页  >  酶联免疫试剂盒  >  Mouse Mms19 ELISA Kit
Mms19 (基因名), MMS19 nucleotide excision repair protein homolog (蛋白名), MMS19_MOUSE.
产品名称:

Mouse Mms19/ MMS19 nucleotide excision repair protein homolog ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

MET18 homolog, MMS19-like protein, Mms19l

检测方法:
ELISA
特异性:
Natural and recombinant mouse MMS19 nucleotide excision repair protein homolog
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Mms19 ELISA Kit
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Mouse Mms19 ELISA Kit
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产品说明书


通用注释


亚单元:
Component of the CIA complex. Component of the MMXD complex, composed of CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with FAM96B; the interaction is direct. Interacts with ERCC2/XPD; the interaction is direct. Interacts with ERCC3/XPB and NCOA3/RAC3. Interacts with RTEL1; the interaction mediates the association of RTEL1 with the CIA complex.


功能:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.


亚细胞位置:
Nucleus Cytoplasm Cytoskeleton Spindle


该产品尚未在任何出版物中被引用。
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