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首页  >  酶联免疫试剂盒  >  Human MMACHC ELISA Kit
MMACHC (基因名), Methylmalonic aciduria and homocystinuria type C protein (蛋白名), MMAC_HUMAN.
产品名称:

Human MMACHC/ Methylmalonic aciduria and homocystinuria type C protein ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

CblC, Cyanocobalamin reductase (cyanide-eliminating)

检测方法:
ELISA
特异性:
Natural and recombinant human Methylmalonic aciduria and homocystinuria type C protein
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human MMACHC ELISA Kit
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Human MMACHC ELISA Kit
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产品说明书


通用注释


亚单元:
Monomer in the absence of bound substrate (PubMed:21697092, PubMed:22642810). Homodimer; dimerization is triggered by binding to FMN or adenosylcobalamin (PubMed:22642810). Heterodimer with MMADHC (PubMed:21071249, PubMed:23415655, PubMed:26483544).


功能:
Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate (PubMed:19700356, PubMed:21697092, PubMed:22642810). Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin (PubMed:19801555, PubMed:22642810, PubMed:25809485). Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen (PubMed:19801555). Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives (PubMed:21071249).


亚细胞位置:
Cytoplasm


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