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首页  >  酶联免疫试剂盒  >  Mouse Map1lc3b ELISA Kit
Map1lc3b (基因名), Microtubule-associated proteins 1A/1B light chain 3B (蛋白名), MLP3B_MOUSE.
产品名称:

Mouse Map1lc3b/ Microtubule-associated proteins 1A/1B light chain 3B ELISA Kit
微管关联蛋白1轻链3β

货号:

E2880m

商标:
EIAab®
监管等级:
别名:

Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, MAP1A/MAP1B light chain 3 B, MAP1A/MAP1B LC3 B, Microtubule-associated protein 1 light chain 3 beta, Map1alc3, Map1lc3

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
78-5000pg/mL
灵敏度:
39.3pg/mL
特异性:
Natural and recombinant mouse Microtubule-associated proteins 1A/1B light chain 3B
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Mouse Map1lc3b ELISA Kit
规格 & 价格: cart
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Mouse Map1lc3b ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤6.4%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤8.5%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

88

82-94

Plasma

90

84-96

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

99-111%

107-117%

96-105%

95-104%

EDTA plasma(n=5)

103-112%

106-116%

95-106%

105-115%

heparin plasma(n=5)

87-97%

 

100-110%

102-114%

108-118%

 

通用注释


亚单元:
3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin. Interacts with FYCO1 (via C-terminus). Interacts with TP53INP1 and TP53INP2 (By similarity). Interacts with TBC1D25 (PubMed:21383079). Directly interacts with SQSTM1; this interaction leads to MAP1LC3B recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy. Interacts with ATG4B, MAPK15 and BNIP3. Interacts with MAPB1, KEAP1, PCM1, OFD1, CEP131, and TECPR2. Interacts with TBC1D5. Found in a complex with UBQLN1 and UBQLN2. Interacts with UBQLN4 (via STI1 1 and 2 domains). Interacts with UBQLN1 in the presence of UBQLN4. Interacts with ATG13. Interacts with FAM134A, FAM134B and FAM134C.


功能:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.


亚细胞位置:
Cytoplasm Cytoskeleton Endomembrane system Lipid-anchor Cytoplasmic vesicle Autophagosome membrane Lipid-anchor Cytoplasmic vesicle Autophagosome LC3-II binds to the autophagic membranes (By similarity). Localizes also to discrete punctae along the ciliary axoneme.


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