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首页  >  酶联免疫试剂盒  >  Bovine MAP1LC3B ELISA Kit
MAP1LC3B (基因名), Microtubule-associated proteins 1A/1B light chain 3B (蛋白名), MLP3B_BOVIN.
产品名称:

Bovine MAP1LC3B/ Microtubule-associated proteins 1A/1B light chain 3B ELISA Kit
微管关联蛋白1轻链3β

货号:

E2880b

商标:
EIAab®
监管等级:
别名:

Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, MAP1A/MAP1B light chain 3 B, MAP1A/MAP1B LC3 B, Microtubule-associated protein 1 light chain 3 beta, MAP1ALC3, MAP1LC3

检测方法:
ELISA
特异性:
Natural and recombinant bovine Microtubule-associated proteins 1A/1B light chain 3B
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Bovine MAP1LC3B ELISA Kit
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Bovine MAP1LC3B ELISA Kit
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产品说明书


通用注释


亚单元:
3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin. Interacts with FYCO1 (via C-terminus). Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1; this interaction leads to MAP1LC3B recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy. Interacts with ATG4B, MAPK15 and BNIP3. Interacts with MAPB1, KEAP1, PCM1, OFD1, CEP131, and TECPR2. Interacts with TBC1D5. Found in a complex with UBQLN1 and UBQLN2. Interacts with UBQLN4 (via STI1 1 and 2 domains). Interacts with UBQLN1 in the presence of UBQLN4. Interacts with ATG13. Interacts with FAM134A, FAM134B and FAM134C.


功能:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.


亚细胞位置:
Cytoplasm Cytoskeleton Endomembrane system Lipid-anchor Cytoplasmic vesicle Autophagosome membrane Lipid-anchor Cytoplasmic vesicle Autophagosome LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ciliary axoneme.


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