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首页  >  酶联免疫试剂盒  >  Bovine MLF1 ELISA Kit
MLF1 (基因名), Myeloid leukemia factor 1 (蛋白名), MLF1_BOVIN.
产品名称:

Bovine MLF1/ Myeloid leukemia factor 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Myelodysplasia-myeloid leukemia factor 1

检测方法:
ELISA
特异性:
Natural and recombinant bovine Myeloid leukemia factor 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Bovine MLF1 ELISA Kit
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Bovine MLF1 ELISA Kit
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产品说明书


通用注释


亚单元:
Interacts with CENPU. Also interacts with NRBP1/MADM, YWHAZ/14-3-3-zeta and HNRPUL2/MANP. NRBP1 recruits a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 then binds to YWHAZ and is retained in the cytoplasm. Retained in the nucleus by binding to HNRPUL2. Binds to COPS3/CSN3 which is required for suppression of RFWD2 and activation of p53.


功能:
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.


亚细胞位置:
Cytoplasm Nucleus Shuttles between the cytoplasm and nucleus.


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