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首页  >  酶联免疫试剂盒  >  Human MKNK2 ELISA Kit
MKNK2 (基因名), MAP kinase-interacting serine/threonine-protein kinase 2 (蛋白名), MKNK2_HUMAN.
产品名称:

Human MKNK2/ MAP kinase-interacting serine/threonine-protein kinase 2 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

MAP kinase signal-integrating kinase 2, MAPK signal-integrating kinase 2, GPRK7, MNK2

检测方法:
ELISA
特异性:
Natural and recombinant human MAP kinase-interacting serine/threonine-protein kinase 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human MKNK2 ELISA Kit
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Human MKNK2 ELISA Kit
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产品说明书


通用注释


亚单元:
Monomer. Interacts with the C-terminal regions of EIF4G1 and EIF4G2; this interaction is promoted when MAPK pathways are repressed but repressed upon ERK proteins activation. Also binds to dephosphorylated MAPK3/ERK1 and MAPK1/ERK2. Isoform 1 interaction with phosphorylated MAPK3/ERK1 and MAPK1/ERK2 protects it from dephosphorylation and inactivation. Isoform 2 interacts with ESR2 and EIF4E in the nucleus.


功能:
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.


亚细胞位置:
Isoform 1 Cytoplasm


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