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首页  >  酶联免疫试剂盒  >  Rat Mapk10 ELISA Kit
Mapk10 (基因名), Mitogen-activated protein kinase 10 (蛋白名), MK10_RAT.
产品名称:

Rat Mapk10/ Mitogen-activated protein kinase 10 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

MAP kinase 10, SAPK-beta, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, p54-beta, Jnk3, Prkm10

检测方法:
ELISA
特异性:
Natural and recombinant rat Mitogen-activated protein kinase 10
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Immunology
Rat Mapk10 ELISA Kit
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Rat Mapk10 ELISA Kit
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产品说明书


通用注释


亚单元:
Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with HDAC9 and MAPKBP1 (By similarity). Interacts with ARRB2; the interaction enhances MAPK10 activation by MAP3K5. Interacts with SARM1.


功能:
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock.


亚细胞位置:
Cytoplasm Membrane Lipid-anchor Nucleus Mitochondrion Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1.


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