Mapk9 (基因名), Mitogen-activated protein kinase 9 (蛋白名), MK09_MOUSE.
Mouse Mapk9/ Mitogen-activated protein kinase 9 ELISA Kit
MAP kinase 9, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2, Jnk2, Prkm9
Natural and recombinant mouse Mitogen-activated protein kinase 9
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with MECOM. Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with NFATC4. Interacts with ATF7; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN. Interacts with BCL10. Interacts with CTNNB1 and GSK3B (By similarity). Interacts with DCLK2.
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).
MSDSKSDGQF | YSVQVADSTF | TVLKRYQQLK | PIGSGAQGIV | CAAFDTVLGI |
NVAVKKLSRP | FQNQTHAKRA | YRELVLLKCV | NHKNIISLLN | VFTPQKTLEE |
FQDVYLVMEL | MDANLCQVIH | MELDHERMSY | LLYQMLCGIK | HLHSAGIIHR |
DLKPSNIVVK | SDCTLKILDF | GLARTACTNF | MMTPYVVTRY | YRAPEVILGM |
GYKENVDIWS | VGCIMAEMVL | HKVLFPGRDY | IDQWNKVIEQ | LGTPSAEFMK |
KLQPTVRNYV | ENRPKYPGIK | FEELFPDWIF | PSESERDKIK | TSQARDLLSK |
MLVIDPDKRI | SVDEALRHPY | ITVWYDPAEA | EAPPPQIYDA | QLEEREHAIE |
EWKELIYKEV | MDWEERSKNG | VKDQPSDAAV | SSKATPSQSS | SINDISSMST |
EHTLASDTDS | SLDASTGPLE | GCR
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