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首页  >  酶联免疫试剂盒  >  Mouse Mapk7 ELISA Kit
Mapk7 (基因名), Mitogen-activated protein kinase 7 (蛋白名), MK07_MOUSE.
产品名称:

Mouse Mapk7/ Mitogen-activated protein kinase 7 ELISA Kit
丝裂原活化蛋白激酶7

货号:

E9212m

商标:
EIAab®
监管等级:
别名:

MAP kinase 7, Big MAP kinase 1, BMK-1, Extracellular signal-regulated kinase 5, ERK-5, Bmk1, Erk5

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.78-50ng/mL
灵敏度:
0.41ng/mL
特异性:
Natural and recombinant mouse Mitogen-activated protein kinase 7
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Mouse Mapk7 ELISA Kit
规格 & 价格: cart
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Mouse Mapk7 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


亚单元:
Interacts with MAP2K5 (By similarity). Forms oligomers. Interacts with MEF2A, MEF2C and MEF2D; the interaction phosphorylates the MEF2s and enhances transcriptional activity of MEF2A, MEF2C but not MEF2D (By similarity). Interacts with SGK1 (By similarity). Interacts with PML (By similarity). Interacts (via N-terminal half) with HSP90AB1-CDC37 chaperone complex in resting cells; the interaction is MAP2K5-independent and prevents MAPK7 from ubiquitination and proteasomal degradation (PubMed:23428871).


功能:
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity). Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.


亚细胞位置:
Isoform 3 Nucleus Isoform 2 is detected only in the nucleus. Translocates to the nucleus upon activation (By similarity).


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