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首页  >  酶联免疫试剂盒  >  Bovine MAPK1 ELISA Kit
MAPK1 (基因名), Mitogen-activated protein kinase 1 (蛋白名), MK01_BOVIN.
产品名称:

Bovine MAPK1/ Mitogen-activated protein kinase 1 ELISA Kit
促分裂原激活蛋白激酶1

货号:

E1206b

商标:
EIAab®
监管等级:
别名:

MAP kinase 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, Mitogen-activated protein kinase 2, MAP kinase 2, ERK2, PRKM1

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.78-50ng/mL
灵敏度:
0.365ng/mL
特异性:
Natural and recombinant bovine Mitogen-activated protein kinase 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Neurosciences
Bovine MAPK1 ELISA Kit
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Bovine MAPK1 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


亚单元:
Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with ADAM15, ARHGEF2, ARRB2, DAPK1 (via death domain), HSF4, IER3, IPO7, MKNK2, DUSP6, MORG1, NISCH, PEA15, SGK1, and isoform 1 of NEK2 (By similarity). Interacts (phosphorylated form) with CAV2 ('Tyr-19'-phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation (By similarity). MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation (By similarity). Interacts with DCC (By similarity). The phosphorylated form interacts with PML (By similarity). Interacts with STYX. Interacts with CDK2AP2.


功能:
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.


亚细胞位置:
Nucleus Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Cytoplasm Cytoplasm Cytoskeleton Spindle PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser-246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. Associated with the spindle during prometaphase and metaphase.


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