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首页  >  酶联免疫试剂盒  >  Human MISP ELISA Kit
MISP (基因名), Mitotic interactor and substrate of PLK1 (蛋白名), MISP_HUMAN.
产品名称:

Human MISP/ Mitotic interactor and substrate of PLK1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Mitotic spindle positioning protein, C19orf21

检测方法:
ELISA
特异性:
Natural and recombinant human Mitotic interactor and substrate of PLK1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human MISP ELISA Kit
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Human MISP ELISA Kit
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产品说明书


通用注释


亚单元:
Associates with F-actin. Interacts with DCTN1; this interaction regulates DCTN1 distribution at the cell cortex. Interacts with PTK2/FAK and MAPRE1.


功能:
Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus.


亚细胞位置:
Cell junction Focal adhesion Cytoplasm Cytoskeleton Cytoplasm Cell cortex Predominantly localizes to cortical actin structures during interphase and mitosis. Present in retraction fibers, which are formed at former adhesion sites during mitosis, and at spicular membrane protrusions in re-attaching cytokinetic cells. Partially colocalizes with cytoplasmic F-actin. Not detected at microtubules at interphase, nor at spindle during mitosis.


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