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首页  >  酶联免疫试剂盒  >  Mouse Micall2 ELISA Kit
Micall2 (基因名), MICAL-like protein 2 (蛋白名), MILK2_MOUSE.
产品名称:

Mouse Micall2/ MICAL-like protein 2 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Junctional Rab13-binding protein, Molecule interacting with CasL-like 2, MICAL-L2, Jrab

检测方法:
ELISA
特异性:
Natural and recombinant mouse MICAL-like protein 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Micall2 ELISA Kit
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Mouse Micall2 ELISA Kit
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产品说明书


通用注释


亚单元:
Interacts with RAB13 (GTP-bound form); competes with RAB8A and is involved in tight junctions assembly. Interacts with RAB8A; competes with RAB13 and is involved in E-cadherin endocytic recycling. Interacts with RAB8B. Interacts (preferentially in opened conformation) with ACTN1 and ACTN4; stimulated by RAB13 activation. Interacts (via CH domain) with the filamins FLNA, FLNB and FLNC (via actin-binding domain).


功能:
Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth.


亚细胞位置:
Cell membrane Peripheral membrane protein Cell junction Tight junction Recycling endosome Cell projection Cytoplasm Cytoskeleton Cytoplasm Cytosol


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