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首页  >  酶联免疫试剂盒  >  Human SPATA18 ELISA Kit
SPATA18 (基因名), Mitochondria-eating protein (蛋白名), MIEAP_HUMAN.
产品名称:

Human SPATA18/ Mitochondria-eating protein ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Spermatogenesis-associated protein 18, MIEAP

检测方法:
ELISA
特异性:
Natural and recombinant human Mitochondria-eating protein
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human SPATA18 ELISA Kit
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Human SPATA18 ELISA Kit
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产品说明书


通用注释


亚单元:
Interacts (via coiled-coil domains) with BNIP3L (via BH3 domain). Interacts (via coiled-coil domains) with BNIP3 (via BH3 domain).


功能:
Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.


亚细胞位置:
Cytoplasm Mitochondrion outer membrane Localizes to the cytoplasm under normal conditions (PubMed:21264228). Relocalizes to mitochondrion outer membrane following cellular stress. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane (PubMed:22292033).


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