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Micu2 (基因名), Calcium uptake protein 2, mitochondrial (蛋白名), MICU2_MOUSE.
产品名称:

Mouse Micu2/ Calcium uptake protein 2, mitochondrial ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

EF-hand domain-containing family member A1, Efha1

检测方法:
ELISA
特异性:
Natural and recombinant mouse Calcium uptake protein 2, mitochondrial
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Micu2 ELISA Kit
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Mouse Micu2 ELISA Kit
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亚单元:
Heterodimer; disulfide-linked; heterodimerizes with MICU1 (PubMed:23409044, PubMed:24560927). Interacts with MCU (PubMed:23409044). The heterodimer formed with MICU1 associates with MCU at low calcium concentration and dissociates from MCU at high calcium level (By similarity). Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1.


功能:
Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:23409044, PubMed:24560927). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering (PubMed:24560927).


亚细胞位置:
Mitochondrion intermembrane space


该产品尚未在任何出版物中被引用。
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