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首页  >  酶联免疫试剂盒  >  Bovine MICU1 ELISA Kit
MICU1 (基因名), Calcium uptake protein 1, mitochondrial (蛋白名), MICU1_BOVIN.
产品名称:

Bovine MICU1/ Calcium uptake protein 1, mitochondrial ELISA Kit
钙吸收蛋白1,线粒体

货号:

E15398b

商标:
EIAab®
监管等级:
别名:

Calcium-binding atopy-related autoantigen 1 homolog, CBARA1

检测方法:
ELISA
特异性:
Natural and recombinant bovine Calcium uptake protein 1, mitochondrial
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine MICU1 ELISA Kit
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Bovine MICU1 ELISA Kit
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产品说明书


通用注释


亚单元:
Homohexamer; in absence of calcium. Forms a homohexamer in absence of calcium and rearranges into a heterodimer in presence of calcium. Heterodimer; disulfide-linked; heterodimerizes with MICU2. The heterodimer formed with MICU2 associates with MCU at low calcium concentration and dissociates from MCU at high calcium level. Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1. Interacts (via polybasic region) with EMRE/SMDT1; the interaction is direct. Interacts (via polybasic region) with MCU (via coiled coil domains); the interaction is direct and precedes formation of the heterodimer with MICU2. Interacts with SLC25A23. Interacts with CHCHD4/MIA40; which introduces the interchain disulfide bond with MICU2.


功能:
Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.


亚细胞位置:
Mitochondrion inner membrane Single-pass membrane protein Mitochondrion intermembrane space The topology is subject to debate.


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