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首页  >  酶联免疫试剂盒  >  Human MICB ELISA Kit
MICB (基因名), MHC class I polypeptide-related sequence B (蛋白名), MICB_HUMAN.
产品名称:

Human MICB/ MHC class I polypeptide-related sequence B ELISA Kit
MHCⅠ类多肽相关序列B

货号:

E15292h

商标:
EIAab®
监管等级:
别名:

MIC-B, PERB11.2

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
31.2-2000pg/mL
灵敏度:
14.4pg/mL
特异性:
Natural and recombinant human MHC class I polypeptide-related sequence B
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Human MICB ELISA Kit
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Human MICB ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


亚单元:
Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST acts as an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of both proteins in ordered structures called immune synapses and also leads to their intercellular transfer. This is associated with a reduction in the cytotoxicity of KLRK1-expressing cells. Binds to human cytomegalovirus glycoprotein UL16 which causes sequestration of MICB in the endoplasmic reticulum and increases resistance to KLRK1-mediated cytotoxicity.


功能:
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.


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