MICB (GeneName), MHC class I polypeptide-related sequence B (ProteinName), MICB_HUMAN.
Human MICB/ MHC class I polypeptide-related sequence B ELISA Kit
Natural and recombinant human MHC class I polypeptide-related sequence B
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST acts as an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of both proteins in ordered structures called immune synapses and also leads to their intercellular transfer. This is associated with a reduction in the cytotoxicity of KLRK1-expressing cells. Binds to human cytomegalovirus glycoprotein UL16 which causes sequestration of MICB in the endoplasmic reticulum and increases resistance to KLRK1-mediated cytotoxicity.
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Cell membrane Single-pass type I membrane protein Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.
MGLGRVLLFL | AVAFPFAPPA | AAAEPHSLRY | NLMVLSQDES | VQSGFLAEGH |
LDGQPFLRYD | RQKRRAKPQG | QWAEDVLGAK | TWDTETEDLT | ENGQDLRRTL |
THIKDQKGGL | HSLQEIRVCE | IHEDSSTRGS | RHFYYDGELF | LSQNLETQES |
TVPQSSRAQT | LAMNVTNFWK | EDAMKTKTHY | RAMQADCLQK | LQRYLKSGVA |
IRRTVPPMVN | VTCSEVSEGN | ITVTCRASSF | YPRNITLTWR | QDGVSLSHNT |
QQWGDVLPDG | NGTYQTWVAT | RIRQGEEQRF | TCYMEHSGNH | GTHPVPSGKV |
LVLQSQRTDF | PYVSAAMPCF | VIIIILCVPC | CKKKTSAAEG | PELVSLQVLD |
QHPVGTGDHR | DAAQLGFQPL | MSATGSTGST | EGA
This product has not yet been referenced specifically in any publications.
"MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility."
"MICB0106 gene polymorphism is associated with ulcerative colitis in central China."
"Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)."
"Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes."
"Associations of MICB with cervical cancer in north-eastern Thais: identification of major histocompatibility complex class I chain-related gene B motifs influencing natural killer cell activation."
"Genetic influence of the nonclassical major histocompatibility complex class I molecule MICB in multiple sclerosis susceptibility."
"[An association between MICB 0106 allele and ulcerative colitis in Chinese Han in Hubei province]."
"Host immune system gene targeting by a viral miRNA."
"Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk."
"Release of MICB molecules by tumor cells: mechanism and soluble MICB in sera of cancer patients."
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